Elevated serum Activin A in chronic obstructive pulmonary disease with skeletal muscle wasting
Clinics
;
74: e981, 2019. tab, graf
Article
in English
| LILACS
| ID: biblio-1011918
ABSTRACT
OBJECTIVE:
Muscle wasting contributes to the reduced quality of life and increased mortality in chronic obstructive pulmonary disease (COPD). Muscle atrophy in mice with cachexia was caused by Activin A binding to ActRIIB. The role of circulating Activin A leading to muscle atrophy in COPD remains elusive.METHODS:
In the present study, we evaluated the relationship between serum levels of Activin A and skeletal muscle wasting in COPD patients. The expression levels of serum Activin A were measured in 78 stable COPD patients and in 60 healthy controls via ELISA, which was also used to determine the expression of circulating TNF-α levels. Total skeletal muscle mass (SMM) was calculated according to a validated formula by age and anthropometric measurements. The fat-free mass index (FFMI) was determined as the fat-free mass (FFM) corrected for body surface area.RESULTS:
Compared to the healthy controls, COPD patients had upregulated Activin A expression. The elevated levels of Activin A were correlated with TNF-α expression, while total SMM and FFMI were significantly decreased in COPD patients. Furthermore, serum Activin A expression in COPD patients was negatively associated with both FFMI and BMI.CONCLUSION:
The above results showed an association between increased circulating Activin A in COPD patients and the presence of muscle atrophy. Given our previous knowledge, we speculate that Activin A contributes to skeletal muscle wasting in COPD.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Muscular Atrophy
/
Pulmonary Disease, Chronic Obstructive
/
Activins
Type of study:
Observational study
/
Risk factors
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2019
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
Affiliated Hospital of Nanjing University Medical School/CN
/
Affiliated Jiangsu University/CN
/
Affiliated Taicang Hospital of Traditional Chinese Medicine/CN
/
Jiangsu University Health Science Center, Yizheng Road, Zhenjiang/CN
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