p38MAPK plays a pivotal role in the development of acute respiratory distress syndrome
Clinics
; 74: e509, 2019.
Article
in En
| LILACS
| ID: biblio-1011922
Responsible library:
BR1.1
ABSTRACT
Acute respiratory distress syndrome (ARDS) is a life-threatening illness characterized by a complex pathophysiology, involving not only the respiratory system but also nonpulmonary distal organs. Although advances in the management of ARDS have led to a distinct improvement in ARDS-related mortality, ARDS is still a life-threatening respiratory condition with long-term consequences. A better understanding of the pathophysiology of this condition will allow us to create a personalized treatment strategy for improving clinical outcomes. In this article, we present a general overview p38 mitogen-activated protein kinase (p38MAPK) and recent advances in understanding its functions. We consider the potential of the pharmacological targeting of p38MAPK pathways to treat ARDS.
Key words
Full text:
1
Index:
LILACS
Main subject:
Respiratory Distress Syndrome, Newborn
/
Inflammation Mediators
/
P38 Mitogen-Activated Protein Kinases
Limits:
Humans
Language:
En
Journal:
Clinics
Journal subject:
MEDICINA
Year:
2019
Type:
Article