Preliminary assessment of anti-α-Gal IgG and IgM levels in patients with patent Plasmodium vivax infection
Mem. Inst. Oswaldo Cruz
;
114: e190145, 2019. tab, graf
Article
in English
| LILACS
| ID: biblio-1040609
ABSTRACT
Anti-α-Gal responses may exert a protective effect in falciparum malaria. However, the biological role of such antibodies is still unknown during Plasmodium vivax infections. We investigated IgG and IgM responses to α-Gal in individuals with vivax malaria. Anti-α-Gal IgG and IgM levels were higher in these patients than in controls, but no significant correlation was found between parasitaemia and anti-α-Gal response, nor between this response and ABO blood group status. This is the first study to investigate anti-α-Gal antibodies in P. vivax-infected patients; a larger survey is necessary to achieve a better understanding of host immune response during vivax malaria.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Plasmodium vivax
/
Immunoglobulin G
/
Immunoglobulin M
/
Antibodies, Anti-Idiotypic
/
Malaria, Vivax
Limits:
Adult
/
Humans
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2019
Type:
Article
Affiliation country:
Brazil
/
United States
Institution/Affiliation country:
Georgia Institute of Technology/US
/
Universidade Federal de Minas Gerais/BR
/
Universidade Federal do Mato Grosso/BR
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