Sporothrix brasiliensis produces the highest levels of oxidative stress in a murine model among the species of the Sporothrix schenckii complex
Rev. Soc. Bras. Med. Trop
; 50(4): 554-557, July-Aug. 2017. graf
Article
in En
| LILACS
| ID: biblio-1041421
Responsible library:
BR1.1
ABSTRACT
Abstract INTRODUCTION:
We compared indicators of oxidative stress in the tissue of mice infected with strains from Sporothrix schenckii complex.METHODS:
Mice were inoculated with Sporothrix brasiliensis, Sporothrix schenckii sensu stricto, Sporothrix globosa, Sporothrix mexicana or Sporothrix albicans. The activity of catalase and glutathione were accessed in the liver and spleen.RESULTS:
Animals infected with S. brasiliensis exhibited splenomegaly and significant decrease in catalase activity, and protein and non-protein thiol content compared to animals infected with the other species.CONCLUSIONS:
Sporothrix brasiliensis exhibits higher pathogenicity compared to other species of the Sporothrix schenckii complex by increasing oxidative stress in animal tissue.Key words
Full text:
1
Index:
LILACS
Main subject:
Spleen
/
Sporotrichosis
/
Oxidative Stress
/
Liver
Limits:
Animals
/
Humans
Country/Region as subject:
America do sul
/
Brasil
Language:
En
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
MEDICINA TROPICAL
Year:
2017
Type:
Article