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The relationship between atopy and neurological manifestations in HTLV-1 infection
Verde, Raquel Crisóstomo Lima; Carneiro Neto, José Abraão; Santos, Silvane Maria Braga; Carvalho, Edgar Marcelino; Lessa, Marcus Miranda.
Affiliation
  • Verde, Raquel Crisóstomo Lima; Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Departamento de Imunologia. Salvador. BR
  • Carneiro Neto, José Abraão; Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Departamento de Imunologia. Salvador. BR
  • Santos, Silvane Maria Braga; Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Departamento de Imunologia. Salvador. BR
  • Carvalho, Edgar Marcelino; Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Departamento de Imunologia. Salvador. BR
  • Lessa, Marcus Miranda; Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Departamento de Imunologia. Salvador. BR
Rev. Soc. Bras. Med. Trop ; 51(2): 207-211, Mar.-Apr. 2018. tab, graf
Article in En | LILACS | ID: biblio-1041456
Responsible library: BR1.1
ABSTRACT
Abstract

INTRODUCTION:

Human T-cell lymphotropic virus type 1 (HTLV-1)induces exaggerated Th1 responses, whereas atopy is associated with exacerbated Th2 responses.

METHODS:

Here, a cross-sectional study compared the prevalence of atopy in HTLV-1 carriers and HAM/TSP patients. It also compared the spontaneous cytokine production in HTLV-1-infected individuals. A retrospective cohort study evaluated the development of neurological manifestations in atopic and non-atopic carriers.

RESULTS:

Atopic HAM/TSP patients with high IFN-γ production exhibited higher IL-5 levels than non-atopic patients. Allergic rhinitis accelerated the development of Babinski signals and overactive bladders.

CONCLUSIONS:

Abnormal Th1 and Th2 responses coexist in HTLV-1-infected individuals and allergic diseases may worsen the clinical course of HTLV-1 infections.
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Full text: 1 Index: LILACS Main subject: HTLV-I Infections / Hypersensitivity, Immediate / Nervous System Diseases Type of study: Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Female / Humans / Male Language: En Journal: Rev. Soc. Bras. Med. Trop Journal subject: MEDICINA TROPICAL Year: 2018 Type: Article
Fulltext
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Full text: 1 Index: LILACS Main subject: HTLV-I Infections / Hypersensitivity, Immediate / Nervous System Diseases Type of study: Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Female / Humans / Male Language: En Journal: Rev. Soc. Bras. Med. Trop Journal subject: MEDICINA TROPICAL Year: 2018 Type: Article