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Effect of artemisinin-piperaquine treatment on the electrocardiogram of malaria patients
Wu, Wanting; Liang, Yuan; Wu, Guangchao; Su, Yinghang; Zhang, Hongying; Zhang, Zhenyan; Deng, Changsheng; Wang, Qi; Huang, Bo; Tan, Bo; Zhou, Chongjun; Song, Jianping.
Affiliation
  • Wu, Wanting; Guangzhou University of Chinese Medicine. Sci-tech Industrial Park. Guanzhou. CN
  • Liang, Yuan; Guangzhou University of Chinese Medicine. Sci-tech Industrial Park. Guanzhou. CN
  • Wu, Guangchao; Guangzhou University of Chinese Medicine. Sci-tech Industrial Park. Guanzhou. CN
  • Su, Yinghang; Guangzhou University of Chinese Medicine. Sci-tech Industrial Park. Guanzhou. CN
  • Zhang, Hongying; Guangzhou University of Chinese Medicine. Sci-tech Industrial Park. Guanzhou. CN
  • Zhang, Zhenyan; Guangzhou University of Chinese Medicine. Sci-tech Industrial Park. Guanzhou. CN
  • Deng, Changsheng; Guangzhou University of Chinese Medicine. Sci-tech Industrial Park. Guanzhou. CN
  • Wang, Qi; Guangzhou University of Chinese Medicine. Sci-tech Industrial Park. Guanzhou. CN
  • Huang, Bo; Guangzhou University of Chinese Medicine. Sci-tech Industrial Park. Guanzhou. CN
  • Tan, Bo; Guangzhou University of Chinese Medicine. Institute of Tropical Medicine. Guangzhou. CN
  • Zhou, Chongjun; Guangzhou University of Chinese Medicine. Institute of Tropical Medicine. Guangzhou. CN
  • Song, Jianping; Guangzhou University of Chinese Medicine. Sci-tech Industrial Park. Guanzhou. CN
Rev. Soc. Bras. Med. Trop ; 52: e20180453, 2019. tab, graf
Article in En | LILACS | ID: biblio-1041531
Responsible library: BR1.1
ABSTRACT
Abstract

INTRODUCTION:

Concern regarding the cardiotoxicity of antimalarials has been renewed because of their potential to cause QT/QTc interval prolongation related to torsade de pointes (TdP). Artemisinin-piperaquine (AP) is considered an effective artemisinin-based combination therapy (ACT) for malaria.

METHODS:

This study involved a retrospective analysis of clinical data of 93 hospitalized malaria patients who had received AP orally. Electrocardiograms (ECGs) were obtained at specific time points in the original study.

RESULTS:

Some cases of QT prolongation were observed. However, no TdP was found.

CONCLUSIONS:

AP may cause QT interval prolongation in some malaria patients but may not lead to TdP.
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Full text: 1 Index: LILACS Main subject: Quinolines / Long QT Syndrome / Malaria, Falciparum / Artemisinins / Antimalarials Type of study: Diagnostic_studies / Observational_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male Language: En Journal: Rev. Soc. Bras. Med. Trop Journal subject: MEDICINA TROPICAL Year: 2019 Type: Article
Fulltext
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Full text: 1 Index: LILACS Main subject: Quinolines / Long QT Syndrome / Malaria, Falciparum / Artemisinins / Antimalarials Type of study: Diagnostic_studies / Observational_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male Language: En Journal: Rev. Soc. Bras. Med. Trop Journal subject: MEDICINA TROPICAL Year: 2019 Type: Article