Ganoderma lucidum, a promising agent possessing antioxidant and anti-inflammatory effects for treating calvarial defects with graft application in rats
Acta cir. bras
;
34(9): e201900904, 2019. tab, graf
Article
in English
| LILACS
| ID: biblio-1054694
ABSTRACT
Abstract Purpose:
Ganoderma lucidum, a kind of mushroom used for its antioxidant, anti-inflammatory, and immunomodulatory activities, was investigated in the present study for its possible healing effect on calvarial defects with bone grafts.Methods:
Wistar male rats (n = 30) were divided into 3 groups 1) the control (defect) group (n = 10), 2) defect and graft group (n = 10), and 3) defect, graft, and G. lucidum treated group (n = 10). The G. lucidum was administered to the rats at 20 mL/kg per day via gastric lavage.Results:
In the defect and graft group, osteonectin positive expression was observed in osteoblast and osteocyte cells at the periphery of the small bone trabeculae within the graft area. In the defect, graft, and G. lucidum treated group, osteonectin expression was positive in the osteoblast and osteocyte cells and positive osteonectin expression in new bone trabeculae. The expression of matrix metalloproteinase-9 (MMP-9) was positive in the inflammatory cells, fibroblast cells, and degenerated collagen fibril areas within the defect area.Conclusion:
This study shows that, with its antioxidant and anti-inflammatory properties, G. Lucidum is an important factor in the treatment of calvarial bone defects.
Full text:
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Index:
LILACS (Americas)
Main subject:
Skull
/
Bone Regeneration
/
Bone Transplantation
/
Reishi
/
Anti-Inflammatory Agents
/
Antioxidants
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2019
Type:
Article
Affiliation country:
Turkey
Institution/Affiliation country:
University of Bingöl/TR
/
University of Dicle/TR
/
University of Katip Çelebi/TR
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