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Disseminated cryptococcosis and hemochromatosis: clues to diagnosis
Nichols, Larry; Rowley, Lindsey; Lall, Ashley.
Affiliation
  • Nichols, Larry; Mercer University School of Medicine. Department of Pathology. Macon. US
  • Rowley, Lindsey; Mercer University School of Medicine. Macon. US
  • Lall, Ashley; Mercer University School of Medicine. Macon. US
Autops. Case Rep ; 10(3): e2020180, 2020. graf
Article in En | LILACS | ID: biblio-1131840
Responsible library: BR26.7
ABSTRACT
Hepatic cirrhosis, diabetes mellitus and iron overload can each independently predispose to cryptococcosis. Hereditary hemochromatosis leads to all three of these predispositions. This report is the case of a patient with chronic hepatitis B virus infection and cirrhosis, who had markedly elevated serum ferritin and 99% transferrin saturation, and developed a leukemoid reaction. Autopsy revealed disseminated cryptococcosis for which the leukemoid reaction was a clue and possible hereditary hemochromatosis of which elevated ferritin and transferrin saturation can be clues. Hereditary hemochromatosis is an important diagnosis clinicians should never miss because early treatment with phlebotomy can be life-saving. Disseminated cryptococcosis can be rapidly diagnosed with serum cryptococcal antigen test and is treatable.
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Full text: 1 Index: LILACS Main subject: Cryptococcosis / Hemochromatosis Type of study: Diagnostic_studies Limits: Humans / Male Language: En Journal: Autops. Case Rep Journal subject: Anatomia / Patologia Cl¡nica / Patologia Legal Year: 2020 Type: Article

Full text: 1 Index: LILACS Main subject: Cryptococcosis / Hemochromatosis Type of study: Diagnostic_studies Limits: Humans / Male Language: En Journal: Autops. Case Rep Journal subject: Anatomia / Patologia Cl¡nica / Patologia Legal Year: 2020 Type: Article