Disseminated cryptococcosis and hemochromatosis: clues to diagnosis
Autops. Case Rep
; 10(3): e2020180, 2020. graf
Article
in En
| LILACS
| ID: biblio-1131840
Responsible library:
BR26.7
ABSTRACT
Hepatic cirrhosis, diabetes mellitus and iron overload can each independently predispose to cryptococcosis. Hereditary hemochromatosis leads to all three of these predispositions. This report is the case of a patient with chronic hepatitis B virus infection and cirrhosis, who had markedly elevated serum ferritin and 99% transferrin saturation, and developed a leukemoid reaction. Autopsy revealed disseminated cryptococcosis for which the leukemoid reaction was a clue and possible hereditary hemochromatosis of which elevated ferritin and transferrin saturation can be clues. Hereditary hemochromatosis is an important diagnosis clinicians should never miss because early treatment with phlebotomy can be life-saving. Disseminated cryptococcosis can be rapidly diagnosed with serum cryptococcal antigen test and is treatable.
Key words
Full text:
1
Index:
LILACS
Main subject:
Cryptococcosis
/
Hemochromatosis
Type of study:
Diagnostic_studies
Limits:
Humans
/
Male
Language:
En
Journal:
Autops. Case Rep
Journal subject:
Anatomia
/
Patologia Cl¡nica
/
Patologia Legal
Year:
2020
Type:
Article