Radiolabeling of cidofovir with technetium-99m and biodistribution studies
Braz. J. Pharm. Sci. (Online)
; 56: e18511, 2020. graf
Article
in En
| LILACS
| ID: biblio-1132051
Responsible library:
BR40.1
Localization: BR40.1
ABSTRACT
Radiolabeling cidofovir with technetium-99m (99mTc-CDV) is an innovative procedure that enables real-time monitoring of the drug. Essays were performed in vitro, showing high radiolabel stability within 24 h. Blood clearance, biodistribution studies, and scintigraphic images were performed in healthy mice in order to evaluate the profile of the drug in vivo. 99mTc-CDV showed biphasic blood circulation time and significant kidney uptake, indicating that 99mTc-CDV is preferentially eliminated by the renal route. Bones also showed important uptake throughout the experiment. In summary, cidofovir was successfully labeled with technetium-99m and might be used in further studies to track the drug.
Key words
Full text:
1
Index:
LILACS
Main subject:
In Vitro Techniques
/
Technetium
/
Cidofovir
Limits:
Animals
Language:
En
Journal:
Braz. J. Pharm. Sci. (Online)
Journal subject:
Farmacologia
/
Teraputica
/
Toxicologia
Year:
2020
Type:
Article