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The association of seminal oxidation reduction potential with sperm parameters in patients with unexplained and male factor ınfertility
Cicek, Ozge Senem Yucel; Kaya, Gozde; Alyuruk, Begum; Doger, Emek; Girisen, Tugba; Filiz, Serdar.
  • Cicek, Ozge Senem Yucel; Kocaeli University. Faculty of Medicine. Department of Obstetrics and Gynecology. Izmit. TR
  • Kaya, Gozde; Kocaeli University. Assisted Reproductive Technologies Clinic. Izmit. TR
  • Alyuruk, Begum; Kocaeli University. Assisted Reproductive Technologies Clinic. Izmit. TR
  • Doger, Emek; Kocaeli University. Faculty of Medicine. Department of Obstetrics and Gynecology. Izmit. TR
  • Girisen, Tugba; Kocaeli University. Assisted Reproductive Technologies Clinic. Izmit. TR
  • Filiz, Serdar; Kocaeli University. Assisted Reproductive Technologies Clinic. Izmit. TR
Int. braz. j. urol ; 47(1): 112-119, Jan.-Feb. 2021. tab, graf
Article in English | LILACS-Express | LILACS (Americas) | ID: biblio-1134303
Responsible library: BR1.1
ABSTRACT
ABSTRACT

Purpose:

Understanding the effects of high oxidation reduction potential (ORP) levels on sperm parameters will help to identify patients with unexplained and male factor infertility who may have seminal oxidative stress and determine if ORP testing is needed. This study aimed to evaluate the association between seminal ORP and conventional sperm parameters. Materials and

Methods:

A total of 58 patients who provided a semen sample for simultaneous evaluation of sperm parameters and ORP between January and September 2019 were enrolled in this retrospective study. To identify normal and high ORP levels, a static ORP (sORP) cut-off value of 1.36mV/106sperm/mL was used. Sperm parameters were compared between infertile men with normal sORP (control group, n=23) and high sORP values (study group, n=35).

Results:

Men with sORP values >1.36mV/106sperm/mL had significantly lower total sperm count (TSC) (p <0.001), sperm concentration (p <0.001) and total motile sperm count (TMSC) (p <0.001). In addition, progressive motility (p=0.04) and fast forward progressive motility (p <0.001) were significantly lower in the study group. A negative correlation was found between sORP and TSC (r=-0.820, p <0.001), sperm concentration (r=-0.822, p <0.001), TMSC (r=-0.808, p <0.001) and progressive motility (r=-0.378, p=0.004). Non-progressive motility positively correlated with sORP (r=0.344, p=0.010).

Conclusions:

This study has shown that TSC, sperm concentration, progressive motility and TMSC are associated with seminal oxidative stress, indicated by a sORP cut-off of 1.36mV/106sperm/mL. Presence of oligozoospermia, reduced progressive motilty or low TMSC in sperm analysis should raise the suspicion of oxidative stress and warrants seminal ROS testing.
Full text: Available Index: LILACS (Americas) Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2021 Type: Article Institution/Affiliation country: Kocaeli University/TR

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Full text: Available Index: LILACS (Americas) Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2021 Type: Article Institution/Affiliation country: Kocaeli University/TR