Superinfection exclusion studies using West Nile virus and Culex flavivirus strains from Argentina
Mem. Inst. Oswaldo Cruz
;
115: e200012, 2020. tab, graf
Article
in English
| LILACS, SES-SP
| ID: biblio-1135267
ABSTRACT
In Argentina, many Flavivirus were recognised including West Nile virus (WNV). During 2009 several strains of Culex Flavivirus (CxFV), an insect-specific flavivirus, were isolated in the same region where circulation of WNV was detected. Hence, the objective of this study was to analyse the effect of co-infection in vitro assays using CxFV and WNV Argentinean strains in order to evaluate if CxFV could affect WNV replication. Our results showed that WNV replication was suppressed when multiplicity of infection (MOI) for CxFV was 10 or 100 times higher than WNV. Nevertheless, in vivo assays are necessary in order to evaluate the superinfection exclusion potential.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
West Nile virus
/
Superinfection
/
Culex
/
Flavivirus
/
Insect Vectors
Limits:
Animals
Country/Region as subject:
South America
/
Argentina
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Year:
2020
Type:
Article
Institution/Affiliation country:
Instituto Nacional de Enfermedades Virales Humanas Dr Julio I Maiztegui/AR
/
Århus University/DK
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