Your browser doesn't support javascript.
loading
Transmission and prevalence of drug-resistant tuberculosis in a Brazilian setting under a directly observed therapy short-course strategy
Latrilha, Fábio Oliveira; Simonsen, Vera; Pinhata, Juliana Maira Watanabe; Brandão, Angela Pires; Galesi, Vera Maria Neder; Waldman, Eliseu Alves; Ferrazoli, Lucilaine.
Affiliation
  • Latrilha, Fábio Oliveira; Instituto Adolfo Lutz. Centro de Bacteriologia. Núcleo de Tuberculose e Micobacterioses. São Paulo. BR
  • Simonsen, Vera; Instituto Adolfo Lutz. Centro de Bacteriologia. Núcleo de Tuberculose e Micobacterioses. São Paulo. BR
  • Pinhata, Juliana Maira Watanabe; Instituto Adolfo Lutz. Centro de Bacteriologia. Núcleo de Tuberculose e Micobacterioses. São Paulo. BR
  • Brandão, Angela Pires; Instituto Adolfo Lutz. Centro de Bacteriologia. Núcleo de Tuberculose e Micobacterioses. São Paulo. BR
  • Galesi, Vera Maria Neder; Secretaria de Saúde do Estado de São Paulo. Centro de Vigilância Epidemiológica Prof. Alexandre Vranjac. Divisão de Controle da Tuberculose. São Paulo. BR
  • Waldman, Eliseu Alves; Universidade de São Paulo. Faculdade de Saúde Pública. São Paulo. BR
  • Ferrazoli, Lucilaine; Instituto Adolfo Lutz. Centro de Bacteriologia. Núcleo de Tuberculose e Micobacterioses. São Paulo. BR
Rev. Soc. Bras. Med. Trop ; 53: e20190404, 2020. tab, graf
Article in En | SES-SP, ColecionaSUS, LILACS | ID: biblio-1136910
Responsible library: BR1.1
ABSTRACT
Abstract

INTRODUCTION:

We aimed to estimate the prevalence and transmission of drug-resistant tuberculosis in a high-burden Brazilian setting under directly observed therapy short-course strategy.

METHODS:

Isolates of culture-confirmed pulmonary tuberculosis patients from Guarulhos, Brazil, diagnosed in October 2007-2011 were subjected to drug susceptibility and IS6110-restriction fragment length polymorphism testing.

RESULTS:

The overall resistance prevalence was 11.5% and the multi-drug resistance rate was 4.2%. Twenty-six (43.3%) of 60 drug-resistant isolates were clustered. Epidemiological relationships were identified in 11 (42.3%) patients; 30.8% of the cases were transmitted in households.

CONCLUSIONS:

Drug-resistant tuberculosis was relatively low and transmitted in households and the community.
Subject(s)
Key words
Fulltext
Add to My VHL
Print
XML
Search on Google

Full text: 1 Index: LILACS Main subject: Polymorphism, Restriction Fragment Length / Brazil / Prevalence / Cross-Sectional Studies / Tuberculosis, Multidrug-Resistant / Directly Observed Therapy / Mycobacterium tuberculosis Type of study: Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Adolescent / Adult / Female / Humans / Male Country/Region as subject: America do sul / Brasil Language: En Journal: Rev. Soc. Bras. Med. Trop Year: 2020 Type: Article
Fulltext
Add to My VHL
Print
XML
Search on Google

Full text: 1 Index: LILACS Main subject: Polymorphism, Restriction Fragment Length / Brazil / Prevalence / Cross-Sectional Studies / Tuberculosis, Multidrug-Resistant / Directly Observed Therapy / Mycobacterium tuberculosis Type of study: Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Adolescent / Adult / Female / Humans / Male Country/Region as subject: America do sul / Brasil Language: En Journal: Rev. Soc. Bras. Med. Trop Year: 2020 Type: Article