Transmission and prevalence of drug-resistant tuberculosis in a Brazilian setting under a directly observed therapy short-course strategy
Rev. Soc. Bras. Med. Trop
;
53: e20190404, 2020. tab, graf
Article
in English
| SES-SP, ColecionaSUS, LILACS
| ID: biblio-1136910
ABSTRACT
Abstract INTRODUCTION:
We aimed to estimate the prevalence and transmission of drug-resistant tuberculosis in a high-burden Brazilian setting under directly observed therapy short-course strategy.METHODS:
Isolates of culture-confirmed pulmonary tuberculosis patients from Guarulhos, Brazil, diagnosed in October 2007-2011 were subjected to drug susceptibility and IS6110-restriction fragment length polymorphism testing.RESULTS:
The overall resistance prevalence was 11.5% and the multi-drug resistance rate was 4.2%. Twenty-six (43.3%) of 60 drug-resistant isolates were clustered. Epidemiological relationships were identified in 11 (42.3%) patients; 30.8% of the cases were transmitted in households.CONCLUSIONS:
Drug-resistant tuberculosis was relatively low and transmitted in households and the community.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Polymorphism, Restriction Fragment Length
/
Brazil
/
Prevalence
/
Cross-Sectional Studies
/
Tuberculosis, Multidrug-Resistant
/
Directly Observed Therapy
/
Mycobacterium tuberculosis
Type of study:
Observational study
/
Prevalence study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Year:
2020
Type:
Article
Institution/Affiliation country:
Instituto Adolfo Lutz/BR
/
Secretaria de Saúde do Estado de São Paulo/BR
/
Universidade de São Paulo/BR
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