Reactivation of Chagas disease after autologous hematopoietic stem cell transplantation
Rev. Soc. Bras. Med. Trop
; 54: e20200143, 2021. graf
Article
in En
| SES-SP, ColecionaSUS, LILACS
| ID: biblio-1143881
Responsible library:
BR1.1
ABSTRACT
Abstract Chagas disease (CD) is a protozoan zoonosis caused by Trypanosoma cruzi. Reactivation of CD occurs via drug-induced immunosuppression before and during transplantation. Here, we report the case of a 62-year-old man diagnosed with classic Hodgkin lymphoma who received highly aggressive conditioning chemotherapy before undergoing stem cell transplantation (SCT). The patient tested positive for CD in pre-transplantation evaluation. The patient exhibited persistent fever and elevated C-reactive protein levels before and after SCT, and was treated with antibiotics. Micro-Strout test showed evidence of trypomastigotes and he was treated with benznidazole until tested negative. Post-transplantation seropositive patients should be screened for possible reactivation.
Key words
Full text:
1
Index:
LILACS
Main subject:
Trypanosoma cruzi
/
Chagas Disease
/
Hematopoietic Stem Cell Transplantation
Limits:
Animals
/
Humans
/
Male
Language:
En
Journal:
Rev. Soc. Bras. Med. Trop
Year:
2021
Type:
Article