Association of the polymorphism Exon 1 (A/O) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment
Rev. Soc. Bras. Med. Trop
; 54: e01452020, 2021. tab, graf
Article
in En
| SES-SP, ColecionaSUS, LILACS
| ID: biblio-1143891
Responsible library:
BR1.1
ABSTRACT
Abstract INTRODUCTION:
We evaluated the association between genetic polymorphisms in exon 1 (A/O alleles) and promoter regions at positions -550 (H/L variant, rs11003125) and -221 (X/Y variant, rs7096206) MBL2 and periportal fibrosis regression.METHODS:
This was a retrospective cohort study involving 114 Brazilians infected with Schistosoma mansoni, who were subjected to follow-up for three years after specific treatment for schistosomiasis to estimate the probability of periportal fibrosis regression.RESULTS:
A risk association was observed between polymorphism at the exon 1 MBL2 and periportal fibrosis regression.CONCLUSIONS:
This study suggests that the polymorphism of exon 1 MBL2 may potentially be used to predict periportal fibrosis regression in this population.Key words
Full text:
1
Index:
LILACS
Main subject:
Schistosomiasis
/
Mannose-Binding Lectin
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Animals
/
Humans
Country/Region as subject:
America do sul
/
Brasil
Language:
En
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
MEDICINA TROPICAL
Year:
2021
Type:
Article