miRNA-195 expression in the tumor tissues of female Brazilian breast cancer patients with operable disease
Clinics
; 76: e2142, 2021. tab, graf
Article
in En
| LILACS
| ID: biblio-1153983
Responsible library:
BR1.1
ABSTRACT
OBJECTIVE:
This study aimed to assess miRNA-195 expression in the tumor tissues from a cohort of Brazilian female breast cancer patients undergoing neoadjuvant chemotherapy (NAC) and evaluate its correlation with various clinicopathological markers.METHODS:
Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to evaluate the miRNA-195 expression in tumor tissues from a cohort of female breast cancer patients undergoing NAC. This expression was then correlated with the occurrence of several distinct breast cancer molecular subtypes and other clinicopathological variables.RESULTS:
A total of 55 patients were included in this study, 28 (50.9%) of whom were treated using NAC. Tumor miRNA-195 expression was suppressed in breast cancer patients, regardless of their exposure to systemic treatments, histological grade, size, nodal status, and tumor-node-metastasis (TNM) staging. This was more pronounced in luminal and triple-negative patients, and patient's response to NAC was correlated with an increase in miRNA-195 expression.CONCLUSION:
miRNA-195 is downregulated in the tumor tissues of Brazilian breast cancer patients regardless of NAC exposure; this reinforces its role as a tumor suppressor and a potential biomarker for chemotherapy response.Key words
Full text:
1
Index:
LILACS
Main subject:
Breast Neoplasms
/
MicroRNAs
Type of study:
Prognostic_studies
Limits:
Female
/
Humans
Country/Region as subject:
America do sul
/
Brasil
Language:
En
Journal:
Clinics
Journal subject:
MEDICINA
Year:
2021
Type:
Article