Drug-Resistant Mycobacterium tuberculosis Isolates from New and Previously Treated TB Patients in China, 2017-2019
Rev. Soc. Bras. Med. Trop
;
54: e0728-2020, 2021. tab, graf
Article
in English
| LILACS
| ID: biblio-1155535
ABSTRACT
Abstract INTRODUCTION:
Mycobacterium tuberculosis (MTB) is a causative agent of tuberculosis (TB) that causes death worldwide.METHODS:
MTB was subjected to phenotypic drug-susceptibility tests (DST), and drug-resistant genes were sequenced.RESULTS:
Previously treated patients were more likely to have positive smear results and exhibit drug resistance. New patients were more likely to be mono SM-resistant and less likely to be INH- and RIF-resistant. The most common mutations were katG (S315T), rpoB (S450L), rpsL (K43R), and embB (M306V).CONCLUSIONS:
The proportion of mono-SM-resistant TB among new patients was higher.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Pharmaceutical Preparations
/
Tuberculosis, Multidrug-Resistant
/
Mycobacterium tuberculosis
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2021
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
Hangzhou Center for Disease Control and Prevention/CN
/
Zhejiang University/CN
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