A controlled pilot study on the efficacy of a low dose antibiotic for the treatment of chronic constipation in patients receiving a high fiber diet / A controlled pilot study on the efficacy of a low dose antibiotic for the treatment of chronic constipation in patients receiving a high fiber diet.
Acta gastroenterol. latinoam
; 43(4): 275-8, 2013 Dec.
Article
in Es
| LILACS, BINACIS
| ID: biblio-1157403
Responsible library:
AR5.1
Localization: [{"text": "AR5.1"}]
ABSTRACT
BACKGROUND AND AIMS:
In a previous uncontrolled experiment, oral vancomycin improved the symptoms (S) of chronic constipation (CC). The aim of this 21 day controlled pilot study was to determine if a low lincomycin dose improved the S of CC patients unresponsive to a high fiber diet.METHODS:
On days 0-to-10, patients were randomized to 500 mg oral lincomycin + high fiber (L + F) or to placebo + high fiber (P + F). Participants and patients were blinded. From days 10-to-21, patients were continued solely on the high fiber diet. The primary efficacy endpoint was the difference in S between L + F and P + F from days 0-to-21 using a visual analog scale (VAS) calibrated from 0 = severe S to 10 = asymptomatic.RESULTS:
The means of all S were significantly improved by L + F but not by P + F. A significant higher proportion of L + F patients increased the VAS > or = 3 points.CONCLUSIONS:
The initial course of L facilitated the effect of F probably by its effect on the colon flora. This sequence of flora-altering biologics + F may serve as model to replace chronic use of drugs.
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Index:
LILACS
Main subject:
Dietary Fiber
/
Lincomycin
/
Constipation
/
Anti-Bacterial Agents
Type of study:
Clinical_trials
Language:
Es
Journal:
Acta gastroenterol. latinoam
Journal subject:
GASTROENTEROLOGIA
Year:
2013
Type:
Article