A nanoemulsion-based delivery system for imatinib and in vitro anticancer efficacy
Braz. J. Pharm. Sci. (Online)
; 56: e18973, 2020. graf
Article
in En
| LILACS
| ID: biblio-1249174
Responsible library:
BR40.1
Localization: BR40.1
ABSTRACT
A self-nanoemulsifying drug delivery system (SNEDDS) composed of ethyl oleate, Tween 80 and polyethylene glycol 600 was prepared as a new route to improve the efficacy of imatinib. The drug-loaded SNEDDS formed nanodroplets of ethyl oleate stabilized by Tween 80 and polyethylene glycol 600 with a diameter of 81.0±9.5 nm. The nanoemulsion-based delivery system was stable for at least two months, with entrapment efficiency and loading capacity of 16.4±0.1 and 48.3±0.2%, respectively. Imatinib-loaded SNEDDS was evaluated for the drug release profiles, and its effectiveness against MCF-7 cell line was investigated. IC50 values for the imatinib-loaded SNEDDS and an imatinib aqueous solution were 3.1 and 6.5 µg mL-1, respectively.
Key words
Full text:
1
Index:
LILACS
Main subject:
In Vitro Techniques
/
Efficacy
/
Imatinib Mesylate
Language:
En
Journal:
Braz. J. Pharm. Sci. (Online)
Journal subject:
Farmacologia
/
Teraputica
/
Toxicologia
Year:
2020
Type:
Article