External Apical Root Resorption and IL-1A, IL-1RN Gene Polymorphisms: A Systematic Review and Meta-Analysis of Prospective Studies
Pesqui. bras. odontopediatria clín. integr
;
21: e0217, 2021. tab, graf
Article
in English
| LILACS, BBO
| ID: biblio-1250442
ABSTRACT
ABSTRACT Objective:
To reconnoiter the IL-1A (-889) and IL-1RN (+2018) gene polymorphisms and their association with EARR. Material andMethods:
The Science Direct, PubMed and Scopus databases were comprehensively searched by two independent reviewers. In addition, the bibliographies of all relevant publications and textbooks were searched manually. A meta-analysis was performed using data available up to May 9, 2020.Results:
A total of 13 and 9 publications were selected for the systematic review and meta-analysis, respectively for both IL-1A and IL-1RN genes. Odds ratio (OR) was used to evaluate the association of the gene polymorphism and the risk of EARR. The risk of EARR was estimated using the overall OR from the published studies. No association was found for IL-1A gene for the risk of EARR. However, the dominant and co-dominant models of IL-1RN gene polymorphism were associated with the risk of EARR.Conclusion:
More studies are warranted to determine the relationship between IL-1A and IL-1RN gene polymorphisms and EARR for a clearer understanding of their interactions.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Orthodontics
/
Polymorphism, Genetic
/
Root Resorption
/
Genetic Heterogeneity
/
Interleukin 1 Receptor Antagonist Protein
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
/
Systematic reviews
Country/Region as subject:
Asia
Language:
English
Journal:
Pesqui. bras. odontopediatria clín. integr
Journal subject:
Dentistry
Year:
2021
Type:
Article
Affiliation country:
Malaysia
/
Saudi Arabia
Institution/Affiliation country:
Jouf University/SA
/
Universiti Sains Malaysia/MY
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