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Long-term lung inflammation is reduced by estradiol treatment in brain dead female rats
Laboratorio de Cirurgia Cardiovascular e Fisiopatologia da Circulacao (LIM-11)Ricardo-da-Silva, Fernanda Yamamoto; Laboratorio de Cirurgia Cardiovascular e Fisiopatologia da Circulacao (LIM-11)Armstrong-Jr, Roberto; Laboratorio de Cirurgia Cardiovascular e Fisiopatologia da Circulacao (LIM-11)Vidal-dos-Santos, Marina; Laboratorio de Cirurgia Cardiovascular e Fisiopatologia da Circulacao (LIM-11)Correia, Cristiano de Jesus; Laboratorio de Cirurgia Cardiovascular e Fisiopatologia da Circulacao (LIM-11)Coutinho e Silva, Raphael dos Santos; Laboratorio de Cirurgia Cardiovascular e Fisiopatologia da Circulacao (LIM-11)Anunciação, Lucas Ferreira da; Laboratorio de Cirurgia Cardiovascular e Fisiopatologia da Circulacao (LIM-11)Moreira, Luiz Felipe Pinho; Leuvenink, Henri Gerrit Derk; Laboratorio de Cirurgia Cardiovascular e Fisiopatologia da Circulacao (LIM-11)Breithaupt-Faloppa, Ana Cristina.
  • Laboratorio de Cirurgia Cardiovascular e Fisiopatologia da Circulacao (LIM-11)Ricardo-da-Silva, Fernanda Yamamoto; Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo. Instituto do Coracao (InCor). Laboratorio de Cirurgia Cardiovascular e Fisiopatologia da Circulacao (LIM-11)Ricardo-da-Silva, Fernanda Yamamoto. Sao Paulo. BR
  • Laboratorio de Cirurgia Cardiovascular e Fisiopatologia da Circulacao (LIM-11)Armstrong-Jr, Roberto; Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo. Instituto do Coracao (InCor). Laboratorio de Cirurgia Cardiovascular e Fisiopatologia da Circulacao (LIM-11)Armstrong-Jr, Roberto. Sao Paulo. BR
  • Laboratorio de Cirurgia Cardiovascular e Fisiopatologia da Circulacao (LIM-11)Vidal-dos-Santos, Marina; Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo. Instituto do Coracao (InCor). Laboratorio de Cirurgia Cardiovascular e Fisiopatologia da Circulacao (LIM-11)Vidal-dos-Santos, Marina. Sao Paulo. BR
  • Laboratorio de Cirurgia Cardiovascular e Fisiopatologia da Circulacao (LIM-11)Correia, Cristiano de Jesus; Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo. Instituto do Coracao (InCor). Laboratorio de Cirurgia Cardiovascular e Fisiopatologia da Circulacao (LIM-11)Correia, Cristiano de Jesus. Sao Paulo. BR
  • Laboratorio de Cirurgia Cardiovascular e Fisiopatologia da Circulacao (LIM-11)Coutinho e Silva, Raphael dos Santos; Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo. Instituto do Coracao (InCor). Laboratorio de Cirurgia Cardiovascular e Fisiopatologia da Circulacao (LIM-11)Coutinho e Silva, Raphael dos Santos. Sao Paulo. BR
  • Laboratorio de Cirurgia Cardiovascular e Fisiopatologia da Circulacao (LIM-11)Anunciação, Lucas Ferreira da; Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo. Instituto do Coracao (InCor). Laboratorio de Cirurgia Cardiovascular e Fisiopatologia da Circulacao (LIM-11)Anunciação, Lucas Ferreira da. Sao Paulo. BR
  • Laboratorio de Cirurgia Cardiovascular e Fisiopatologia da Circulacao (LIM-11)Moreira, Luiz Felipe Pinho; Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo. Instituto do Coracao (InCor). Laboratorio de Cirurgia Cardiovascular e Fisiopatologia da Circulacao (LIM-11)Moreira, Luiz Felipe Pinho. Sao Paulo. BR
  • Leuvenink, Henri Gerrit Derk; University of Groningen. University Medical Centre Groningen. Department of Surgery. NL
  • Laboratorio de Cirurgia Cardiovascular e Fisiopatologia da Circulacao (LIM-11)Breithaupt-Faloppa, Ana Cristina; Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo. Instituto do Coracao (InCor). Laboratorio de Cirurgia Cardiovascular e Fisiopatologia da Circulacao (LIM-11)Breithaupt-Faloppa, Ana Cristina. Sao Paulo. BR
Clinics ; 76: e3042, 2021. tab, graf
Article in English | LILACS | ID: biblio-1286068
ABSTRACT

OBJECTIVES:

Lung transplantation is limited by the systemic repercussions of brain death (BD). Studies have shown the potential protective role of 17β-estradiol on the lungs. Here, we aimed to investigate the effect of estradiol on the long-lasting lung inflammatory state to understand a possible therapeutic application in lung donors with BD.

METHODS:

Female Wistar rats were separated into 3 groups BD, subjected to brain death (6h); E2-T0, treated with 17β-estradiol (50 μg/mL, 2 mL/h) immediately after brain death; and E2-T3, treated with 17β-estradiol (50 μg/ml, 2 ml/h) after 3h of BD. Complement system activity and macrophage presence were analyzed. TNF-α, IL-1β, IL-10, and IL-6 gene expression (RT-PCR) and levels in 24h lung culture medium were quantified. Finally, analysis of caspase-3 gene and protein expression in the lung was performed.

RESULTS:

Estradiol reduced complement C3 protein and gene expression. The presence of lung macrophages was not modified by estradiol, but the release of inflammatory mediators was reduced and TNF-α and IL-1β gene expression were reduced in the E2-T3 group. In addition, caspase-3 protein expression was reduced by estradiol in the same group.

CONCLUSIONS:

Brain death-induced lung inflammation in females is modulated by estradiol treatment. Study data suggest that estradiol can control the inflammatory response by modulating the release of mediators after brain death in the long term. These results strengthen the idea of estradiol as a therapy for donor lungs and improving transplant outcomes.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Pneumonia / Brain Death Limits: Animals Language: English Journal: Clinics Journal subject: Medicine Year: 2021 Type: Article Affiliation country: Brazil / Netherlands Institution/Affiliation country: Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo/BR / University of Groningen/NL

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Full text: Available Index: LILACS (Americas) Main subject: Pneumonia / Brain Death Limits: Animals Language: English Journal: Clinics Journal subject: Medicine Year: 2021 Type: Article Affiliation country: Brazil / Netherlands Institution/Affiliation country: Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo/BR / University of Groningen/NL