Effect of calcium dobesilate in preventing contrast-induced nephropathy in patients with diabetes and chronic kidney disease
Clinics
;
76: e2942, 2021. tab, graf
Article
in English
| LILACS
| ID: biblio-1345813
ABSTRACT
OBJECTIVES:
This study assessed the protective effect of calcium dobesilate against contrast-induced nephropathy (CIN) after coronary angiography (CAG) or percutaneous coronary intervention (PCI) in patients with diabetes and chronic kidney disease (CKD).METHODS:
A total of 130 patients with diabetes and CKD estimated glomerular filtration rate 30-90 mL/min/1.73m2 were enrolled and included in the analysis. They were divided into experimental (n=65) and control groups (n=65). Patients in the experimental group were administered oral calcium dobesilate (500 mg) three times daily for 2 days before and 3 days after the procedure. The serum creatinine (SCr), cystatin C (Cys C), and neutrophil gelatinase-associated lipocalin (NGAL) levels were measured before and after the procedure.RESULTS:
The mean SCr level at 24h after the procedure was found to be significantly lower in the experimental group than in the control group (79.1±19.6 μmol/L vs. 87.0±19.3 μmol/L, p=0.023). However, the Cys C and NGAL levels were not significantly different between the two groups at all measurement time points (all p>0.05). The incidence of CIN defined by the SCr level was significantly lower in the experimental group than in the control group (3 [4.6%] vs. 13 [20.0%], p=0.017). However, the incidence of CIN defined by the Cys C level was not statistically different between the two groups (7 [10.8%] vs. 7 [10.8%], p=1.000).CONCLUSIONS:
This study revealed that calcium dobesilate has no preventive effect against CIN in patients with diabetes and CKD.
Full text:
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Index:
LILACS (Americas)
Main subject:
Calcium Dobesilate
/
Diabetes Mellitus
/
Renal Insufficiency, Chronic
/
Percutaneous Coronary Intervention
/
Kidney Diseases
Limits:
Humans
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2021
Type:
Article
Affiliation country:
China
/
South Korea
Institution/Affiliation country:
Korea University Guro Hospital/KR
/
The Second Hospital of Tianjin Medical University/CN
/
the Second Hospital of Tianjin Medical University/CN
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