Exploring the expression profile of vitamin D receptor and its related long non-coding RNAs in patients with acute lymphoblastic leukemia
Rev. Assoc. Med. Bras. (1992, Impr.)
; 67(8): 1113-1117, Aug. 2021. tab, graf
Article
in En
| LILACS
| ID: biblio-1346981
Responsible library:
BR1.1
ABSTRACT
SUMMARY OBJECTIVE:
Acute lymphoblastic leukemia (ALL) is the most common type of childhood cancer. Previous studies have indicated the involvement of vitamin D receptor (VDR) and related long noncoding RNAs (lncRNAs) signaling in the pathophysiology of several cancers. However, their contribution to ALL remains to be elucidated.METHODS:
In this case-control study, 30 patients with newly diagnosed ALL and 30 age- and sex-matched healthy children were selected. Then, the level of 25(OH) vitamin D and the expression of VDR and four VDR-related lncRNAs were assessed.RESULTS:
No significant difference in serum 25(OH) vitamin D was observed between patients with ALL (20.42±6.5 ng/mL) and healthy subjects (25.45±11 ng/mL). In addition, the expression of MALAT-1, HOTAIR, and P-21 was not statistically significant between the two groups. However, a significant reduction in VDR and H19 expression was observed in patients with ALL (p<0.05).CONCLUSIONS:
25(OH) vitamin D insufficiency was evident in both groups. VDR and H19 signaling might be contributed to the pathogenesis of ALL, which needs further investigations.Key words
Full text:
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Index:
LILACS
Main subject:
Receptors, Calcitriol
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
RNA, Long Noncoding
Type of study:
Observational_studies
Limits:
Child
/
Humans
Language:
En
Journal:
Rev. Assoc. Med. Bras. (1992, Impr.)
Journal subject:
EducaÆo em Sa£de
/
GestÆo do Conhecimento para a Pesquisa em Sa£de
/
MEDICINA
Year:
2021
Type:
Article