5-aminolevulinic Acid and Surgical Margin Analysis in Calvarial Metastasis with Pericranium or Dural Extension: Technical Note
Arq. bras. neurocir
; 39(3): 207-212, 15/09/2020.
Article
in En
| LILACS
| ID: biblio-1362422
Responsible library:
BR1.1
ABSTRACT
Metastasis to the calvarium with direct pericranium or dural infiltration may be treated with radical surgical removal in selected cases. We describe microsurgical resection of calvarial metastases with fluorescence-guided technique using 5-aminolevulinic acid (5-ALA) in two female patients with breast cancer. Fluorescence findings were positive in both cases. Margins in the scalp and dural layer were 5-ALA negative at the end of surgical removal. Intraoperative pathology was performed in all cases to confirm if oncological limits were free of disease. One case was 5-ALA positive in the outer layer of the dura-mater and another in the pericranium. At the end of the removal in both cases, the surgicalmargins were 5-ALA fluorescence-free. Intraoperative pathology confirmed oncological limits of the resection. 5-aminolevulinic acid fluorescence-guided surgery for calvarial metastases with pericranium and/or dural extension seems to be a safe and reliable method to aid the surgical margins for complete removal, possibly delaying or avoiding adjuvant irradiation for progression control.
Key words
Full text:
1
Index:
LILACS
Main subject:
Skull Base Neoplasms
/
Fluorescence
/
Aminolevulinic Acid
/
Neoplasm Metastasis
Type of study:
Diagnostic_studies
/
Observational_studies
Language:
En
Journal:
Arq. bras. neurocir
Journal subject:
Cirurgia
/
NEUROCIRURGIA
Year:
2020
Type:
Article