Protective effect of polysaccharides isolated from the seeds of Cuscuta chinensis Lam. on 5-fluorouracil-induced intestinal mucositis in mice
Acta cir. bras
; 37(2): e370204, 2022. graf
Article
in En
| LILACS, VETINDEX
| ID: biblio-1374066
Responsible library:
BR68.1
ABSTRACT
Purpose:
To evaluate the protective effect of Cuscuta chinensis Lam. polysaccharides (PCCL) on 5-fluorouracil-(5-FU)-induced intestinal mucositis (IM) in mice.Methods:
PCCL was orally administered at a dose of 20 mg·kg1 for 7 days and its protective effect on 5-FU-induced IM (5-FU, 50 mg·kg1 for 5 days) was evaluated by monitoring changes in body weight, degree of diarrhea, levels of tissue inflammatory factors (tumor necrosis factor α, interleukin 6, and interleukin 1ß levels), apoptosis rates, and the expression levels of caspase-3, Bax and Bcl-2.Results:
The severity of mucosal injury (as reflected by body weight changes, degree of diarrhea, height of villi, and damage to crypts) was significantly attenuated by PCCL administration. PCCL also reduced the levels of tissue inflammatory factors, the apoptosis rate, and the expression of caspase-3 and Bax, and increased Bcl-2 expression.Conclusions:
PCCL administration may be significantly protective against 5-FU-induced IM by inhibiting apoptosis and regulating the abnormal inflammation associated with it.Subject(s)
Key words
Full text:
1
Index:
LILACS
Main subject:
Polysaccharides
/
Cuscuta
/
Mucositis
/
Fluorouracil
Limits:
Animals
Language:
En
Journal:
Acta cir. bras
Journal subject:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2022
Type:
Article