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Effect of weekly versus daily primaquine on Plasmodium vivax malaria recurrences: A real-life cohort study
Brito-Sousa, Jose Diego; Phanor, Jeffe; Balieiro, Patricia Carvalho da Silva; Silva-Neto, Alexandre Vilhena; Cordeiro, Jady Shayenne Mota; Vitor-Silva, Sheila; Mendes, Maxwell; Sampaio, Vanderson Souza; Melo, Gisely Cardoso de; Lacerda, Marcus; Monteiro, Wuelton.
Affiliation
  • Brito-Sousa, Jose Diego; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado. Instituto de Pesquisa Clínica Carlos Borborema. Manaus. BR
  • Phanor, Jeffe; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado. Instituto de Pesquisa Clínica Carlos Borborema. Manaus. BR
  • Balieiro, Patricia Carvalho da Silva; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado. Instituto de Pesquisa Clínica Carlos Borborema. Manaus. BR
  • Silva-Neto, Alexandre Vilhena; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado. Instituto de Pesquisa Clínica Carlos Borborema. Manaus. BR
  • Cordeiro, Jady Shayenne Mota; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado. Instituto de Pesquisa Clínica Carlos Borborema. Manaus. BR
  • Vitor-Silva, Sheila; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado. Instituto de Pesquisa Clínica Carlos Borborema. Manaus. BR
  • Mendes, Maxwell; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado. Instituto de Pesquisa Clínica Carlos Borborema. Manaus. BR
  • Sampaio, Vanderson Souza; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado. Instituto de Pesquisa Clínica Carlos Borborema. Manaus. BR
  • Melo, Gisely Cardoso de; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado. Instituto de Pesquisa Clínica Carlos Borborema. Manaus. BR
  • Lacerda, Marcus; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado. Instituto de Pesquisa Clínica Carlos Borborema. Manaus. BR
  • Monteiro, Wuelton; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado. Instituto de Pesquisa Clínica Carlos Borborema. Manaus. BR
Rev. Soc. Bras. Med. Trop ; Rev. Soc. Bras. Med. Trop;55: e0738, 2022. tab, graf
Article in En | LILACS-Express | LILACS | ID: biblio-1376352
Responsible library: BR1.1
ABSTRACT
ABSTRACT

Background:

Although primaquine (PQ) is indicated for G6PD-deficient patients, data on weekly PQ use in Brazil are limited.

Methods:

We aimed to investigate malaria recurrences among participants receiving daily and weekly PQ treatments in a real-life setting of two municipalities in the Amazon between 2019 and 2020.

Results:

Patients receiving weekly PQ treatment had a lower risk of recurrence than those receiving daily PQ treatment (risk ratio 0.62, 95% confidence interval 0.41-0.94), using a model adjusted for study site.

Conclusions:

Weekly PQ use did not increase the risk of malaria recurrence. Further studies with larger populations are warranted.
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Full text: 1 Index: LILACS Type of study: Etiology_studies / Observational_studies / Risk_factors_studies Language: En Journal: Rev. Soc. Bras. Med. Trop Journal subject: MEDICINA TROPICAL Year: 2022 Type: Article / Project document
Fulltext
Add to My VHL
Print
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Full text: 1 Index: LILACS Type of study: Etiology_studies / Observational_studies / Risk_factors_studies Language: En Journal: Rev. Soc. Bras. Med. Trop Journal subject: MEDICINA TROPICAL Year: 2022 Type: Article / Project document