Synthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivatives
Braz. J. Pharm. Sci. (Online)
;
58: e191026, 2022. tab, graf
Article
in English
| LILACS
| ID: biblio-1384003
ABSTRACT
In this present study, 63 different 5-[4-methyl-2-(pyridin-3/4-yl)thiazole-5-yl]-4-substituted-3-substituted benzylthio-4H-1,2,4-triazole derivatives were synthesized, and evaluated for their in vitro antimicrobial activity against various human pathogenic microorganisms and antioxidant activity. The derivatives were synthesized in a multi-step synthesis procedure including triazole and thiazole ring closure reactions, respectively. The synthesized derivatives (A1-24; B1-39) were screened for their antibacterial, antifungal, and antioxidant activities compared to standard agents. The derivatives possessing 3-pyridyl moiety particularly exhibited relatively high antibacterial activity (MIC= < 3.09-500 µg/mL) against Gram-positive bacteria, and compounds possessing 4-pyridyl moiety showed remarkable antioxidant activity
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Pyridines
/
Thiazoles
/
Triazoles
/
Methods
/
Antioxidants
Language:
English
Journal:
Braz. J. Pharm. Sci. (Online)
Journal subject:
Farmacologia
/
Teraputica
/
Toxicologia
Year:
2022
Type:
Article
Affiliation country:
Turkey
Institution/Affiliation country:
Anadolu University/TR
/
Burdur Mehmet Akif Ersoy University/TR
/
Eskisehir Osmangazi University/TR
/
Medipol University/TR
/
Trakya University/TR
Similar
MEDLINE
...
LILACS
LIS