Prevalencia del anticuerpo anti receptor de fosfolipasa A2 sérico e histológico en pacientes con nefropatía membranosa en un Centro Universitario / Phospholipase A2 receptor antigen antibodies in serum and renal biopsies of patients with membranous nephropathy
Rev. méd. Chile
; 149(1): 7-12, ene. 2021. tab, ilus
Article
in Es
| LILACS
| ID: biblio-1389340
Responsible library:
CL126.2
ABSTRACT
BACKGROUND:
The discovery of the phospholipase A2 receptor antigen and its highly specific autoantibody (anti-PLA2R Ab) was useful for the diagnosis and follow-up of patients with membranous nephropathy (MN). Thus, some international guidelines recommend not performing renal biopsy in patients with positive serum anti-PLA2R Ab.Aim:
To evaluate the prevalence of anti-PLA2R Ab in serum and renal tissue samples from Chilean patients with primary MN. MATERIAL ANDMETHODS:
Twenty-eight patients aged 50 ± 14 years (20 males) with biopsy-proven primary MN plus a negative workup for secondary causes were included. Measurements of serum and renal histologic anti-PLA2R Ab were performed. The relationship between the findings of serum and tissue anti-PLA2R Ab was evaluated.RESULTS:
Fifteen patients (54 %) had anti-PLA2R Ab presence in serum and 19 patients (68%) had positive anti-PLA2R Ab in the renal biopsy. All patients with positive serum anti-PLA2R Ab had positive antibodies on immunohistochemistry.Conclusions:
Serum anti-PLA2R Ab is potentially useful in the diagnosis of patients with suspected primary MN in Chilean population.Key words
Full text:
1
Index:
LILACS
Main subject:
Glomerulonephritis, Membranous
/
Receptors, Phospholipase A2
Type of study:
Guideline
/
Prevalence_studies
/
Risk_factors_studies
/
Screening_studies
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
America do sul
/
Chile
Language:
Es
Journal:
Rev. méd. Chile
Journal subject:
MEDICINA
Year:
2021
Type:
Article