¿Son equivalentes los diferentes métodos para estimar la función renal en los adultos mayores? / Comparison of different methods to estimate glomerular filtration rate in older adults
Rev. méd. Chile
; 149(2): 187-195, feb. 2021. tab, ilus
Article
in Es
| LILACS
| ID: biblio-1389443
Responsible library:
CL1.1
ABSTRACT
Background:
Glomerular filtration rate (GFR) estimation in older adults using a creatinine clearance/24-hour (CrCl) or an equation based on serum creatinine, are often considered equivalent by clinicians.Aim:
To compare GFR estimated (eGFR) with the available equations and measured CrCl in patients ≥ 70 years. A secondary aim was to know the differences in chronic kidney disease (CKD) classification, when using the different eGFR formulas. Patients andMethods:
In 144 patients aged 77 ± 5 years (58% men), CrCl was measured and GFR was estimated using MDRD, CKD-EPI, BIS-1 and FAS formulas. The eGFR and the stage of CKD were compared according to the different equations used.Results:
GFR estimated by MDRD and CKD-EPI equations was 7.8 and 8.4 mL/min/1.73 m2 lower than 24-hour ClCr, respectively. This difference was even greater using the BIS-1 and FAS equations. Twenty-four-hour CrCl classified 47.2% of the patients in a category of renal function > 60 mL/min/1.73 m2, while MDRD and CKD-EPI equations classified just over a third, and BIS-1 and FAS formulas around 20% of the patients.Conclusions:
The practice of considering equivalent the GFR estimation using the creatinine-based equations with measured creatinine clearance in older adults should be reconsidered, because their results differ markedly.Key words
Full text:
1
Index:
LILACS
Main subject:
Renal Insufficiency, Chronic
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
Es
Journal:
Rev. méd. Chile
Journal subject:
MEDICINA
Year:
2021
Type:
Article