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Inorganic element profile of medicinal Cannabis extracts consumed by pediatric patients
Santos, Lisia Maria Gobbo dos; Vicentini Neto, Santos Alves; Barata-Silva, Cristiane; Fonseca, Mayssa de Andrade; Magalhães, Carolina Duque; Carvalho, Virgínia Martins; Rocha, Ernesto Díaz; Jacob, Silvana do Couto.
  • Santos, Lisia Maria Gobbo dos; Fiocruz. Instituto Nacional de Controle de Qualidade em Saúde -INCQS. Departamento Química. Rio de Janeiro. BR
  • Vicentini Neto, Santos Alves; Fiocruz. Instituto Nacional de Controle de Qualidade em Saúde -INCQS. Departamento Química. Rio de Janeiro. BR
  • Barata-Silva, Cristiane; Fiocruz. Instituto Nacional de Controle de Qualidade em Saúde -INCQS. Departamento Química. Rio de Janeiro. BR
  • Fonseca, Mayssa de Andrade; Fiocruz. Instituto Nacional de Controle de Qualidade em Saúde -INCQS. Departamento Química. Rio de Janeiro. BR
  • Magalhães, Carolina Duque; Fiocruz. Instituto Nacional de Controle de Qualidade em Saúde -INCQS. Departamento Química. Rio de Janeiro. BR
  • Carvalho, Virgínia Martins; Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Rio de Janeiro. BR
  • Rocha, Ernesto Díaz; Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Rio de Janeiro. BR
  • Jacob, Silvana do Couto; Fiocruz. Instituto Nacional de Controle de Qualidade em Saúde -INCQS. Departamento Química. Rio de Janeiro. BR
Braz. J. Pharm. Sci. (Online) ; 58: e20176, 2022. tab
Article in English | LILACS | ID: biblio-1403748
ABSTRACT
Abstract The increasing number of reports of web-based experiences on the success of Cannabis-based therapies in controlling seizures in children suffering from refractory epilepsy have led to efforts by governments and associations to a recent change in legislation. The Brazilian Health Regulatory Agency (ANVISA) allowed the import of Cannabis extracts in 2015 and the registration of the first industrialized drug in 2017. In 2019, ANVISA approved procedures for the granting of a Sanitary Authorization for manufacturing and imports, establishing marketing requirements, prescribing, dispensing, monitoring and surveillance of cannabis products for medicinal purposes. Similar to other consumer products of health concern, is necessary to ensure the quality and health safety of these products worldwide. The aim of the present study to evaluate the presence of As, Cd, Pb, Ni, Cu, Co, Cr and Mn present in Cannabis extracts and resins used in the treatment of pediatric patients with neurological diseases. Samples (48 national and 24 imported) were analyzed by Inductively Coupled Plasma Mass Spectrometry - ICP-MS. The imported extracts presented more homogeneous inorganic element values, while national extracts showed varied levels, thus indicating the highest health risk.
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Full text: Available Index: LILACS (Americas) Main subject: Patients / Cannabis / Plant Extracts / Medical Marijuana Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Fiocruz/BR / Universidade Federal do Rio de Janeiro/BR

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Full text: Available Index: LILACS (Americas) Main subject: Patients / Cannabis / Plant Extracts / Medical Marijuana Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2022 Type: Article Affiliation country: Brazil Institution/Affiliation country: Fiocruz/BR / Universidade Federal do Rio de Janeiro/BR