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S-allyl Cysteine and Taurine revert peripheral metabolic and lipid profile in non-insulin-dependent diabetes mellitus animals: Combination vs Monotherapy
Rais, Nadeem; Parveen, Kehkashan; Ahmad, Rizwan; Siddiqui, Waseem Ahmad; Nadeem, Ayasha; Ved, Akash.
Affiliation
  • Rais, Nadeem; Bhagwant University. Department of Pharmacy. Ajmer. IN
  • Parveen, Kehkashan; Aligarh Muslim University. Interdisciplinary Biotechnology Unit. Aligarh. IN
  • Ahmad, Rizwan; Vivek College of Technical Education. Department of Pharmacy. Bijnor. IN
  • Siddiqui, Waseem Ahmad; Aligarh Muslim University. Interdisciplinary Biotechnology Unit. Aligarh. IN
  • Nadeem, Ayasha; Jamia Hamdard. SUMER. Department of kulliyat. New Delhi. IN
  • Ved, Akash; Goel Institute of Pharmaceutical Sciences. Lucknow. IN
Braz. J. Pharm. Sci. (Online) ; 58: e201183, 2022. tab, graf
Article in En | LILACS-Express | LILACS | ID: biblio-1420376
Responsible library: BR1.1
ABSTRACT
Abstract The present study was designed to evaluate the beneficial synergistic effects of S-allyl Cysteine (SAC) and Taurine (TAU) on hyperglycemia, lipid profile and renal damage markers in type 2 diabetes mellitus (T2DM) in rats. Experimental T2DM was developed by administering an intraperitoneal single dose of nicotinamide (NA; 230 mg/kg) and streptozotocin (STZ; 65 mg/ kg) in adult rats. Control and diabetic rats were treated with SAC (150 mg/kg); TAU (200 mg/ kg) or SAC and TAU (75+100 mg/kg) combination for four weeks. Measurements of traditional markers of kidney toxicity in serum, such as blood urea nitrogen (BUN), serum creatinine (Scr), and alkaline phosphatase (ALP), together with serum cholesterol/triglyceride such as serum total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and very low-density lipoprotein cholesterol (VLDL-C) may yield a snapshot of renal damage and lipid profile in NA/STZ-treated rats. The variation in levels of fasting blood glucose, glycosylated hemoglobin, insulin and lipid profile was significantly augmented in SAC/TAU treatment group. The diabetic group showed elevated renal injury markers in serum, which were decreased significantly by SAC/TAU treatment. Thus the results of the experiment clearly indicate the potential of the SAC/TAU combination in improving diabetic complications.
Key words

Full text: 1 Index: LILACS Language: En Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2022 Type: Article

Full text: 1 Index: LILACS Language: En Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2022 Type: Article