Effect of ascorbic acid and epidermal growth factor in a rat tibia defect
Acta cir. bras
; 38: e381623, 2023. tab, graf, ilus
Article
in En
| LILACS, VETINDEX
| ID: biblio-1439108
Responsible library:
BR68.1
ABSTRACT
Purpose:
Bone repair aims to restore the anatomical, biomechanical, and functional integrity of the affected structure. Here we study the effects of ascorbic acid (AA) and epidermal growth factor (EGF) applied in a single dose and in combination on the repair of a noncritical bone defect model.Methods:
Twenty-four rats were divided into four groups an intact G-1 control group, and three groups that underwent a noncritical bone defect in the right tibia G-2 treated with AA, G-3 treated with EGF, and G-4 treated with AA in combination with EGF. After 21 days of treatment, rats were sacrificed, the tibias were dissected and a destructive biomechanical analysis of three-point flexion test was performed in a universal testing machine; the values of stiffness, resistance, maximum energy, and energy at maximum load were statistically compared.Results:
G-3 and G-4 recovered the biomechanical properties of strength and stiffness of an intact tibia 3 weeks after their application. Not so the energy and energy at maximum load. For G-2, only the stiffness of an intact tibia was recovered.Conclusion:
EGF and AA-EGF applied to a noncritical bone defect in the rat tibia favors the recovery of bone resistance and stiffness.Key words
Full text:
1
Index:
LILACS
Main subject:
Ascorbic Acid
/
Tibia
/
Biocompatible Materials
/
Epidermal Growth Factor
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Acta cir. bras
Journal subject:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2023
Type:
Article