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Estandarización de la batería neuropsicológica de funciones ejecutivas y lóbulos frontales BaNFE-2 en muestra paraguaya con esclerosis múltiple tipo recaída remisión
Doldán, María Celeste; Díaz De Bedoya, Fernando Hamuy; Nacimiento, Belen; Fleitas, Cynthia Verónica; Galeano, Martha Sady; Ramirez, María Teresa; Gonzalez, Lourdes; Martinez, Montserrat; Paredes Ramírez, Paola; Rolon, Marta Beatriz.
  • Doldán, María Celeste; s.af
  • Díaz De Bedoya, Fernando Hamuy; s.af
  • Nacimiento, Belen; s.af
  • Fleitas, Cynthia Verónica; s.af
  • Galeano, Martha Sady; s.af
  • Ramirez, María Teresa; s.af
  • Gonzalez, Lourdes; s.af
  • Martinez, Montserrat; s.af
  • Paredes Ramírez, Paola; s.af
  • Rolon, Marta Beatriz; s.af
Rev. Inst. Med. Trop ; 18(1)jun. 2023.
Article in Spanish | LILACS-Express | LILACS | ID: biblio-1449251
RESUMEN
Introducción: la esclerosis múltiple (EM), enfermedad crónica del sistema nervioso (SNC), compromete significativamente la cognición. Su prevalencia en Paraguay es 9,2/100.000 habitantes, 72% con recaída remisión (EMRR) e incidencia de 2-3mujeres/hombre, afecta más a personas en edad productiva, con altos costos económicos y afectivos. Objetivos: caracterizar al paciente con EMRR, evaluar sus funciones ejecutivas (FEs) con BaNFE-2; establecer valores de corte ajustados al país. Metodología: con fundamento en teoría de la neurociencia cognitiva, diseño no experimental, cuantitativo, descriptivo, empírico, retrospectivo y transversal; técnica psicométrica y entrevista neuropsicológica en una muestra por conveniencia de 40 pacientes, 82,5% mujeres y edad 25-55 años (37,78±7,89). Resultados: se reportaron datos demográficos y clínicos, se caracterizaron las escalas de BaNFE-2 cuya consistencia interna resultó significativa. Se obtuvo 52,5% de alteración en la escala prefrontal y 42,5% en FEs; relaciones significativas con escolaridad, discapacidad física (DF), cantidad de brotes y deterioro cognitivo (DC); diferencias significativas por sexo, escolaridad, DF y DC. Se calcularon puntuaciones tipificadas por escolaridad, z<-1 establece el corte entre normalidad y alteración. Conclusión: las pruebas de BaNFE-2 perfilan la afectación del tiempo de ejecución, atención, memoria de trabajo y FEs. Este estudio aporta baremos ajustados al país y abre una novedosa línea de investigación aplicando BaNFE-2 en EM.
ABSTRACT
Introduction: Multiple sclerosis (MS) is a chronic, neurodegenerative, inflammatory disease of the central nervous system (CNS) that significantly compromises cognitive functions. In Paraguay, it occurs with a prevalence of 9.2/100,000 inhabitants, 72% in the clinical form of relapsing remission (RRMS) and an incidence of 2 to 3 women/men, affecting more people of productive age with high economic and emotional costs. Objectives: To characterize the Paraguayan patient with RRMS, to assess the state of their executive functions (EFs) with the BaNFE-2 battery, and to establish cut-off values adjusted to the country. Methods: Research based on the theory of cognitive neuroscience of non-experimental, quantitative and descriptive design for analytical purposes. It is empirical, retrospective and cross-sectional. The psychometric technique and neuropsychological interview were used in a convenience sample of 40 patients aged 25 to 55 (37.78 ± 7.89) and 82.5% women. Results: Demographic and clinical data of the participants were reported. The BaNFE-2 coded and normalized scales were statistically characterized, the internal consistency of which was significant. 52.5% of the alteration was obtained in the anterior prefrontal scale and 42.5% in FEs; there are significant relationships with schooling, physical disability (PD), number of outbreaks and cognitive impairment (CI); there were also significant differences by sex, education, PD and CI. Standardized scores adjusted for schooling were calculated such that z<-1 establishes the cutoff between normality and abnormality. Conclusion: BaNFE-2 battery tests profile the affectation of execution time, attention, working memory, and FEs. This study provides the adjusted scales for the country and opens a new line of research applying the BaNFE-2 battery in people with MS.

Full text: Available Index: LILACS (Americas) Type of study: Risk factors Country/Region as subject: South America / Paraguay Language: Spanish Journal: Rev. Inst. Med. Trop Journal subject: Tropical Medicine Year: 2023 Type: Article

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Full text: Available Index: LILACS (Americas) Type of study: Risk factors Country/Region as subject: South America / Paraguay Language: Spanish Journal: Rev. Inst. Med. Trop Journal subject: Tropical Medicine Year: 2023 Type: Article