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Bacteriologic profile, antibiotics resistance pattern, and outcomes of patients admitted to Lancet General Hospital from June 2022 to June 2023: A retrospective cohort study
Demissie, Zekewos; Nurlegn, Serkalem; Zemedkun, Nahom; Demssis, Yidnekachew; Mekuriy, Bethel; Beyene, Eyob; Getachew, Seifemichael; Mekonnen, Desalew; Birhanu, Yohannes; Alemayehu, Brook; Silesh, Nebiyat; Sintayehu, Gelila; Admasu, Dawit; Zewdie, Kibruyisfaw.
Affiliation
  • Demissie, Zekewos; Department of Internal Medicine Lancet General Hospital, Addis Ababa, Ethiopia. Addis Ababa. ET
  • Nurlegn, Serkalem; Department of Internal Medicine Lancet General Hospital, Addis Ababa, Ethiopia. Addis Ababa. ET
  • Zemedkun, Nahom; Lancet General Hospital, Addis Ababa, Ethiopia. Addis Ababa. ET
  • Demssis, Yidnekachew; Department of Internal Medicine Lancet General Hospital, Addis Ababa, Ethiopia. Addis Ababa. ET
  • Mekuriy, Bethel; Lancet General Hospital, Addis Ababa, Ethiopia. Addis Ababa. ET
  • Beyene, Eyob; Department of Internal Medicine, Addis Ababa University, Addis Ababa, Ethiopia. Addis Ababa. ET
  • Getachew, Seifemichael; Department of Internal medicine, St. Paul Millennium Medical College, Addis Ababa, Ethiopia. Addis Ababa. ET
  • Mekonnen, Desalew; Department of Internal Medicine, Addis Ababa University, Addis Ababa, Ethiopia. Addis Ababa. ET
  • Birhanu, Yohannes; Department of Internal Medicine, Addis Ababa University, Addis Ababa, Ethiopia. Addis Ababa. ET
  • Alemayehu, Brook; Department of Internal Medicine Lancet General Hospital, Addis Ababa, Ethiopia. Addis Ababa. ET
  • Silesh, Nebiyat; Department of Internal Medicine Lancet General Hospital, Addis Ababa, Ethiopia. Addis Ababa. ET
  • Sintayehu, Gelila; Department of Internal Medicine Lancet General Hospital, Addis Ababa, Ethiopia. Addis Ababa. ET
  • Admasu, Dawit; Department of Surgery, Lancet General Hospital, Addis Ababa, Ethiopia. Addis Ababa. ET
  • Zewdie, Kibruyisfaw; Department of Neurosurgery, Addis Ababa University, Addis Ababa, Ethiopia. Addis Ababa. ET
Ethiop. Med. j ; Ethiop. med. j. (Online);62(1): 15-24, 2024. figures, tables
Article in En | AIM | ID: biblio-1524541
Responsible library: CG1.1
ABSTRACT
Background Prior studies indicated increased antimicrobial resistance in Ethiopia, with related health, economic, and environmental costs. Knowing an institutions and population microbiologic profile allows for proper antibi-otic treatment, which substantially impact patients' outcomes such as healthcare related costs, morbidity, and mortality. The current study assessed the bacteriologic profile, resistance pattern, and treatment outcome in Lancet General Hospital. Method A retrospective cohort study on the bacteriologic profile, antibiotics resistance pattern, and outcome of patients was done on 128 eligible patients who were admitted to Lancet General Hospital from June 2022 to June 2023. Data from all hospitalized patients with culture-confirmed infection were analyzed. SPSS version 26.0 was used to analyze the data. Association between independent and dependent variables was analyzed using binary logistic regression model. Results Gram-negative bacteria were recovered in 77% of the cases. Extended-spectrum beta-lactamase producing Enterobacteriaceae was found in 37.5% (54) isolates and carbapenem resistant bacteria were identified in 27.8% of patients. In-hospital mortality from multidrug resistant bacterial infection was 14.8%. Age ≥ 65 years, presence of septic shock, and presence of carbapenem-resistant bacteria were independently associated with in-creased in-hospital mortality. Conclusion High number of resistant microorganisms was isolated, and increased mortality was documented from infections caused by carbapenem-resistant bacteria. Multi-center studies should be done to determine the extent of resistant organisms in health facilities throughout the country. epidemiology, and the findings should be factored into clinical decision making and program design for disease prevention, screening, and treatment. It also calls for further prospective research to learn more about the conditions in the context of additional relevant personal and clinical characteristics
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Full text: 1 Index: AIM Type of study: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Male Language: En Journal: Ethiop. Med. j / Ethiop. med. j. (Online) Year: 2024 Type: Article

Full text: 1 Index: AIM Type of study: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Male Language: En Journal: Ethiop. Med. j / Ethiop. med. j. (Online) Year: 2024 Type: Article