Multiple cutaneous melanomas associated with gastric and brain metastases
An. bras. dermatol
; 91(5,supl.1): 98-100, Sept.-Oct. 2016. tab, graf
Article
in En
| LILACS
| ID: biblio-837940
Responsible library:
BR1.1
ABSTRACT
Abstract The occurrence of multiple primary melanomas in a single individual is rare. Most commonly, malignant melanocytic lesions subsequent to the initial diagnosis of melanoma are secondary cutaneous metastases. We report a patient with gastrointestinal bleeding from gastric metastasis of cutaneous melanoma. During clinical evaluation and staging, we discovered a brain metastasis associated with 3 synchronous primary cutaneous melanomas. We suggest the research on the mutation in the cyclin-dependent kinase inhibitor 2A (CDKN2A) (INK4a) in such cases. We also emphasize the importance of clinical examination and dermoscopy of the entire tegument, even after a malignant melanocytic lesion is identified.
Key words
Full text:
1
Index:
LILACS
Main subject:
Skin Neoplasms
/
Stomach Neoplasms
/
Brain Neoplasms
/
Melanoma
/
Neoplasms, Multiple Primary
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Humans
Language:
En
Journal:
An. bras. dermatol
Journal subject:
DERMATOLOGIA
Year:
2016
Type:
Article