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Peripheral polyneuropathy in severely obese patients with metabolic syndrome but without diabetes: Association with low HDL-cholesterol / Polineuropatia periférica em pacientes obesos graves com síndrome metabólica sem diabetes: associação com baixo HDL-colesterol
Nienov, Otto Henrique; Matte, Luciana; Dias, Lisiane Stefani; Schmid, Helena.
Affiliation
  • Nienov, Otto Henrique; Universidade Federal do Rio Grande do Sul. Health Sciences Graduate Program, Obstetrics and Gynecology. Porto Alegre. BR
  • Matte, Luciana; Universidade Federal do Rio Grande do Sul. Health Sciences Graduate Program, Obstetrics and Gynecology. Porto Alegre. BR
  • Dias, Lisiane Stefani; Universidade Federal do Rio Grande do Sul. Health Sciences Graduate Program, Obstetrics and Gynecology. Porto Alegre. BR
  • Schmid, Helena; Universidade Federal do Rio Grande do Sul. Health Sciences Graduate Program, Obstetrics and Gynecology. Porto Alegre. BR
Rev. Assoc. Med. Bras. (1992, Impr.) ; Rev. Assoc. Med. Bras. (1992, Impr.);63(4): 324-331, Apr. 2017. tab, graf
Article in En | LILACS | ID: biblio-842558
Responsible library: BR1.1
ABSTRACT
Summary

Introduction:

The purpose of this study was to evaluate the prevalence of peripheral polyneuropathy (PPN) in subjects with grade II and III obesity (Ob-II,III) and metabolic syndrome (MetS) but without diabetes and to investigate possible associated factors.

Method:

A cross-sectional study was performed in non-diabetic Ob-II,III,MetS patients using the Michigan Neuropathy Screening Instrument (MNSI) to assess the presence of PPN.

Results:

A total of 24 of 218 non-diabetic Ob-II,III,MetS patients had PPN. Based on univariate analysis, serum levels of LDL-cholesterol (p=0.046) were significantly associated with PPN, while serum triglycerides (p=0.118) and low HDL-cholesterol (p=0.057) showed a tendency toward this association. On a Poisson regression analysis, when the three possible associations were included, low HDL-cholesterol (p=0.047) remained independently associated.

Conclusion:

In non-diabetic Ob-II,III,MetS patients, PPN defined by the MNSI showed a high prevalence and was associated with low levels of HDL-cholesterol. In order to diagnose that complication, neurological evaluation should be performed in these patients.
RESUMO
Resumo

Objetivo:

Avaliar a prevalência da polineuropatia periférica (PNP) em indivíduos obesos graus II e III com síndrome metabólica (Ob-II,III,SM) sem diabetes e buscar possíveis fatores associados.

Método:

Em um estudo transversal, realizado em indivíduos Ob-II,III,SM e sem diagnóstico de diabetes, o Instrumento de Screening de Michigan (MNSI) foi utilizado para avaliar a presença de PNP.

Resultados:

Um total de 24 de 218 pacientes Ob-II,III,SM e sem diabetes tinham PNP. Quando observamos as associações com PNP em uma análise univariada, níveis séricos de LDL-colesterol (p=0.046) estiveram significativamente associados e houve também uma tendência à associação com níveis séricos de triglicerídeos (p=0.118) e baixo HDL-colesterol (p=0.057). Em uma análise de regressão de Poisson, quando as três possíveis associações foram incluídas, baixo HDL-colesterol (p=0.047) manteve-se independentemente associado.

Conclusão:

Em pacientes Ob-II,III,SM, mas sem diabetes, a PNP definida pelo MNSI tem uma prevalência elevada e está associada a baixos níveis de HDL-colesterol. Para diagnóstico dessa complicação, recomenda-se realizar o exame neurológico desses pacientes.
Subject(s)
Key words

Full text: 1 Index: LILACS Main subject: Polyneuropathies / Obesity, Morbid / Metabolic Syndrome / Hypoalphalipoproteinemias Type of study: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male Country/Region as subject: America do sul / Brasil Language: En Journal: Rev. Assoc. Med. Bras. (1992, Impr.) Journal subject: Educa‡Æo em Sa£de / GestÆo do Conhecimento para a Pesquisa em Sa£de / MEDICINA Year: 2017 Type: Article

Full text: 1 Index: LILACS Main subject: Polyneuropathies / Obesity, Morbid / Metabolic Syndrome / Hypoalphalipoproteinemias Type of study: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male Country/Region as subject: America do sul / Brasil Language: En Journal: Rev. Assoc. Med. Bras. (1992, Impr.) Journal subject: Educa‡Æo em Sa£de / GestÆo do Conhecimento para a Pesquisa em Sa£de / MEDICINA Year: 2017 Type: Article