High-fat diet or low-protein diet changes peritoneal macrophages function in mice
Nutrire Rev. Soc. Bras. Aliment. Nutr
;
41: 1-9, Dec. 2016. tab, ilus
Article
in English
| LILACS
| ID: biblio-880607
ABSTRACT
BACKGROUND: Obesity and protein malnutrition are major food problems nowadays, affecting billions of people around the world. The nutrition transition that has occurred in recent decades is changing the nutritional profile, reducing malnutrition and increasing the percentage of obese people. The innate immune response is greatly influenced by diet, with significant changes in both malnutrition and obesity. Therefore, we investigate the effects of protein malnutrition and obesity in nutritional and immunological parameters in mice. RESULTS: Peritoneal macrophages of malnourished animals showed reduced functions of adhesion, spreading, and fungicidal activity; production of hydrogen peroxide and nitric oxide were lower, reflecting changes in the innate immune response. However, the high-fat animals had macrophage functions slightly increased. CONCLUSIONS: Animals subjected to low-protein diet have immunosuppression, and animals subjected to high-fat diet increased visceral adipose tissue and the presence of an inflammatory process with increased peritoneal macrophage activity and similar systemic changes to metabolic syndrome.
Full text:
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Index:
LILACS (Americas)
Main subject:
Immunosuppression Therapy
/
Diet, Protein-Restricted
/
Intra-Abdominal Fat
/
Diet, High-Fat
Limits:
Animals
Language:
English
Journal:
Nutrire Rev. Soc. Bras. Aliment. Nutr
Journal subject:
Nutritional Sciences
Year:
2016
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
University of Sao Paulo/BR
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