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Inhibition of cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) by D-005 (A lipid extract of Acrocomia crispa fruits) / [Inhibición de la ciclooxigenasa (COX) y la 5-lipooxigenasa (5-LOX) por el D-005 (extracto lipidico del fruto de la Acrocomia crispa)
Pérez, Yohani; Oyarzábal, Ambar; Sierra, Roxana; Mas, Rosa; Molina, Vivian; Jiménez, Sonia; González, Victor.
Affiliation
  • Pérez, Yohani; National Centre for Scientific Research. Centre of Natural Products. Pharmacology Department. Havana City. CU
  • Oyarzábal, Ambar; National Centre for Scientific Research. Centre of Natural Products. Pharmacology Department. Havana City. CU
  • Sierra, Roxana; National Centre for Scientific Research. Centre of Natural Products. Pharmacology Department. Havana City. CU
  • Mas, Rosa; National Centre for Scientific Research. Centre of Natural Products. Pharmacology Department. Havana City. CU
  • Molina, Vivian; National Centre for Scientific Research. Centre of Natural Products. Pharmacology Department. Havana City. CU
  • Jiménez, Sonia; National Centre for Scientific Research. Centre of Natural Products. Pharmacology Department. Havana City. CU
  • González, Victor; National Centre for Scientific Research. Centre of Natural Products. Pharmacology Department. Havana City. CU
Bol. latinoam. Caribe plantas med. aromát ; 16(3): 319-328, mayo 2017. tab, ilus
Article in En | LILACS | ID: biblio-882011
Responsible library: CL1.1
ABSTRACT
This study was aimed to investigate whether the a lipid extract from Acrocomia crispa fruits (D-005) inhibits COX and 5-LOX enzyme activities in vitro. This study demonstrates that D-005 inhibits markedly and in a dose dependent manner COX-2 and 5-LOX activities. The dual inhibition of COX-2 and 5-LOX supports further research on the potential anti-inflammatory effect of D-005.
RESUMEN
El objetivo de este estudio fue investigar si el extracto lipídico de los frutos de Acrocomia crispa (D-005) inhibe in vitro las actividades de las enzimas COX y 5-LOX. Este estudio demuestra que el D-005 inhibe marcadamente y de manera dosis dependiente las actividades de la COX-2 y 5-LOX. La inhibición dual de la COX-2 y 5-LOX soportan futuras investigaciones sobre el potencial efecto anti-inflamatorio del D-005.
Subject(s)
Key words
Full text: 1 Index: LILACS Main subject: Plant Extracts / Lipoxygenase Inhibitors / Cyclooxygenase Inhibitors / Arecaceae / Anti-Inflammatory Agents Limits: Animals Language: En Journal: Bol. latinoam. Caribe plantas med. aromát Journal subject: BOTANICA / MEDICINA / Plantas Medicinais / Terapias Complementares Year: 2017 Type: Article
Full text: 1 Index: LILACS Main subject: Plant Extracts / Lipoxygenase Inhibitors / Cyclooxygenase Inhibitors / Arecaceae / Anti-Inflammatory Agents Limits: Animals Language: En Journal: Bol. latinoam. Caribe plantas med. aromát Journal subject: BOTANICA / MEDICINA / Plantas Medicinais / Terapias Complementares Year: 2017 Type: Article