Tumor del estroma gastrointestinal y trasplante renal / Gastrointestinal stromal tumor and renal transplant
Medicina (B.Aires)
; 77(4): 334-346, ago. 2017. ilus
Article
in Es
| LILACS
| ID: biblio-894490
Responsible library:
BR1.1
RESUMEN
El tumor estromal gastrointestinal (GIST) representa alrededor del 1% de todos los tumores digestivos y su aparición en pacientes trasplantados renales es infrecuente. Aproximadamente el 95% muestra tinción positiva para c-kit/CD117. DOG1 es un anticuerpo recientemente descrito que se sobre-expresa en los GIST, incluso en c-kit/ CD117 negativos. El diagnóstico preciso de GIST resulta imperativo, debido a la disponibilidad y la creciente eficacia de los inhibidores de la tirosina quinasa en estos tumores, incluso en el subgrupo c-kit/ CD117 negativo. Se presenta el caso de una mujer trasplantada renal inicialmente con GIST en intestino delgado y débil positividad para CD117 tratada con cirugía y recidiva tumoral a los tres años, pérdida de la expresión CD117 y tinción positiva para DOG1. Recibió tratamiento exitoso con imatimib sin presentar recaída tumoral durante un seguimiento de cinco años.
ABSTRACT
Gastrointestinal stromal tumor (GIST) accounts for nearly 1% of all gastrointestinal tumors. Its association with renal transplantation is not frequent. Approximately 95% of GIST show staining for CD177. DOG1 is a recently described monoclonal antibody that shows positivity even in the absence of CD177 staining. The diagnosis of GIST should be pursued because of the availability of very effective treatments with tyrosine-kinase inhibitors. Herein, we describe the case of a woman with renal transplant who presented a small bowel GIST and weak positivity for CD177, treated initially with surgery. Tumor recurrence was documented 3 years later and histopatology showed loss of CD177 staining and positivity for DOG1. She was treated with imatimib without further recurrence after five years of follow up.
Key words
Full text:
1
Index:
LILACS
Main subject:
Biomarkers, Tumor
/
Kidney Transplantation
/
Proto-Oncogene Proteins c-kit
/
Gastrointestinal Stromal Tumors
/
Anoctamin-1
/
Neoplasm Proteins
Limits:
Female
/
Humans
Language:
Es
Journal:
Medicina (B.Aires)
Journal subject:
MEDICINA
Year:
2017
Type:
Article