Analyzing the neuropsychological characteristics and changes in serum markers of patients with chronic cerebral circulation insufficiency
Rev. Assoc. Med. Bras. (1992)
;
64(1): 41-46, Jan. 2018. tab, graf
Article
in English
| LILACS
| ID: biblio-896422
ABSTRACT
Summary Objective:
To investigate the neuropsychological characteristics and changes in CRP, S100B, MBP, HSP-7, and NSE in serum.Method:
Sixty-six (66) patients treated in our hospital as CCCI group were chosen for our study, and 90 patients with depression were selected as the depression group. The patients in both groups were examined with CT perfusion, depression, anxiety and cognition evaluation. Their serum CRP, S100B, MBP, HSP-70 and NSE levels were detected. Neuropsychological and serum markers characteristics were compared.Results:
The CBF and CBV in bilateral basal ganglia, frontal lobes, greater oval center, brain stem, and left and right regions of occipital lobes of the patients in CCCI group were significantly lower than in the depression group. The HAMD and HAMA scores of CCCI group patients were significantly lower than in the depression group; CCCI group performed better regarding attention, memory, abstract terms and delayed recall. CCCI also had significantly higher total scores than the depression group. Serum CRP, S100B, MBP, HSP-70 and NSE levels in CCCI group were significantly higher than in the depression group. The differences reach statistical significance (p<0.05).Conclusion:
CCCI patients who are accompanied by minor depressive disorder have different degrees of cognitive impairment and experience a significant rise in serum CRP, S100B, MBP, HSP-70 and NSE.
Full text:
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Index:
LILACS (Americas)
Main subject:
Anxiety
/
Biomarkers
/
Cerebrovascular Circulation
/
Cerebrovascular Disorders
/
Depressive Disorder
Type of study:
Diagnostic study
/
Etiology study
/
Risk factors
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Rev. Assoc. Med. Bras. (1992)
Year:
2018
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
Yantaishan Hospital/CN
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