Interleukin-10 haplotypes are not associated with acute cerebral ischemia or high-risk transcranial Doppler in a newborn cohort of 395 children with sickle cell anemia
Rev. bras. hematol. hemoter
; 39(2): 108-114, Apr.-June 2017. tab, graf
Article
in En
| LILACS
| ID: biblio-898907
Responsible library:
BR408.1
Localization: BR408.1
ABSTRACT
ABSTRACT Background:
The etiology of stroke, a severe complication of sickle cell anemia, involves inflammatory processes. However, the pathogenetic mechanisms are unknown. The aim of this study was to evaluate the influence of interleukin-10 polymorphisms and haplotypes on the risk of acute cerebral ischemia and high-risk transcranial Doppler in 395 children with sickle cell anemia from the state of Minas Gerais, Brazil.Methods:
Interleukin-10 haplotypes were determined by polymerase chain reaction-restriction fragment length polymorphism and sequencing. The outcomes studied were acute cerebral ischemia and high-risk transcranial Doppler. Clinical data were retrieved from the children's records.Results:
There was no statistically significant difference in the frequencies of polymorphisms and haplotypes between children with and without acute cerebral ischemia or children with or without high-risk transcranial Doppler. These data are consistent with a previous report that showed an absence of association between interleukin-10 plasma levels and high-risk transcranial Doppler velocity in children with sickle cell anemia.Conclusion:
Interleukin-10 haplotypes were not associated with the risk of acute cerebral ischemia or high-risk transcranial Doppler velocity in children with sickle cell anemia from the state of Minas Gerais, Brazil.Key words
Full text:
1
Index:
LILACS
Main subject:
Polymorphism, Genetic
/
Interleukin-10
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Ultrasonography, Doppler, Transcranial
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Stroke
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Anemia, Sickle Cell
Type of study:
Etiology_studies
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Risk_factors_studies
Limits:
Child
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Female
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Humans
/
Male
Language:
En
Journal:
Rev. bras. hematol. hemoter
Journal subject:
HEMATOLOGIA
Year:
2017
Type:
Article
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Project document