Galectina-3: experiencia en pacientes chilenos con diagnóstico de insuficiencia cardíaca descompensada / Galectin-3 levels in patients hospitalized for decompensated heart failure
Rev. méd. Chile
;
145(6): 734-740, June 2017. tab, graf
Article
in Spanish
| LILACS
| ID: biblio-902538
RESUMEN
Background:
Galectin-3 (Gal-3) is a mediator of myocardial fibrosis involved in cardiac remodeling and a potential new prognosis marker in heart failure (HF).Aim:
To measure Gal-3 at the moment of discharge in patients hospitalized for HF and its association with different variables. Material andMethods:
Patients hospitalized for decompensated HF from four hospitals between August 2014 and March 2015, were included. Demographic, clinical and laboratory variables were recorded at the time of admission. At discharge, a blood sample was withdrawn to measure Gal-3 and brain natriuretic propeptide (Pro-BNP). Patients were separated in two groups, according to the level of Gal-3 (using a cutoff value of 17.8 ng/mL), comparing clinical and laboratory values between groups.Results:
We included 52 patients with HF aged 70 ± 17 years (42% females). Functional capacity was III-IV in 46% of patients and the ejection fraction was 34.9 ± 13.4%. Pro-BNP values at discharge were 5,323 ± 8,665 pg/mL. Gal-3 values were 23.8 ± 16.6 ng/mL. Sixty percent of patients had values over 17.8 ng/mL. Those with elevated Gal-3 levels were older (75 ±16 and 62 ± 15 years, respectively, p = 0.025) and were hypertensive in a higher proportion (90.5% and 57.1% respectively, p = 0.021).Conclusions:
In patients hospitalized for HF, Gal-3 levels are higher in older and hypertensive subjects.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Galectin 3
/
Heart Failure
/
Hospitalization
Type of study:
Diagnostic study
/
Observational study
/
Prevalence study
/
Prognostic study
/
Risk factors
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Chile
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2017
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Hospital del Salvador/CL
Similar
MEDLINE
...
LILACS
LIS