Epigenética del síndrome de ovario poliquístico / Epigenetics of polycystic ovary syndrome
Rev. méd. Chile
; 145(7): 907-915, jul. 2017. tab, graf
Article
in Es
| LILACS
| ID: biblio-902563
Responsible library:
CL1.1
ABSTRACT
Polycystic ovarian syndrome (PCOS) is an endocrine and metabolic dysfunction, highly prevalent in women in their reproductive years. Hyperandrogenism, oligo-ovulation, polycystic ovarian morphology are the main features of this syndrome. PCOS is a genetic disorder with a multifactorial etiology and has a strong link with environmental components. It is frequently associated with obesity and insulin resistance. Recently, epigenetic mechanisms have been involved in the pathogenesis of PCOS. Several studies showed that methylation in DNA and miRNAs is altered in women with PCOS in blood, serum, adipose tissue, granulose cells and theca. This evidence indicates that women with PCOS have a different epigenetic regulation, which might be triggered by an adverse intrauterine environment or by postnatal environmental elements such as diet and or obesity.
Key words
Full text:
1
Index:
LILACS
Main subject:
Polycystic Ovary Syndrome
/
Gene Expression Regulation, Neoplastic
/
DNA Methylation
/
MicroRNAs
/
Epigenesis, Genetic
Limits:
Female
/
Humans
Language:
Es
Journal:
Rev. méd. Chile
Journal subject:
MEDICINA
Year:
2017
Type:
Article