CYP1A1, CYP1B1, GSTM1 and GSTT1 genetic variants and breast cancer risk in Mexican women / Variantes genéticas de CYP1A1, CYP1B1, GSTM1 y GSTT1, y riesgo de cáncer mamario en mujeres mexicanas
Salud pública Méx
; 59(5): 540-547, Sep.-Oct. 2017. tab
Article
in En
| LILACS
| ID: biblio-903806
Responsible library:
BR1.1
ABSTRACT
Abstract Objective:
To evaluate if variants in the genes CYP1A1 (T3801C and A4889G), CYP1B1 (G119T), GSTM1 (indel) and GSTT1 (indel) are associated with breast cancer (BC) among Mexican women. Materials andmethods:
952 incident cases with histologically confirmed BC were matched by age (± 5 years) and zone of residence with 998 healthy population controls. Genetic variants in genes CYP1A1, CYP1B1, GSTM1 and GSTT1were genotyped by allelic discrimination and multiplex PCR. In a subsample of women, 105 markers for ancestry were determined.Results:
An increased BC risk, independent of other BC risk factors, was observed among carriers of CYP1B1 G119T genotype (T/T vs. G/G OR=1.9; 95%CI 1.4-2.5).Conclusion:
Our results support the existence of genetic susceptibility for BC conferred by CYP1B1 G119T variant among Mexican women.RESUMEN
Resumen Objetivo:
Evaluar si las variantes en los genes CYP1A1 (T3801C y A4889G), CYP1B1 (G119T), GSTM1 (indel) yGSTT1 (indel), se asocian con el cáncer de mama (CM) en mujeres mexicanas. Material ymétodos:
Se parearon por edad (± 5 años) y zona de residencia 952 casos incidentes de CM histológicamente confirmado con 998 controles sanos poblacionales. Se genotipificaron variantes en los genes CYP1A1, CYP1B1, GSTM1 y GSTT1 por discriminación alélica y PCR multiplex. En una submuestra de mujeres, se determinaron 105 marcadores de ancestría.Resultados:
Se observó un aumento del riesgo de CM, independiente de otros factores de riesgo, entre las portadoras del genotipo CYP1B1 G119T (T/T vs. G/G RM=1.9; 95%CI 1.4-2.5).Conclusiones:
Nuestros resultados soportan la existencia de susceptibilidad genética para CM conferida por la variante CYP1B1 G119T en mujeres mexicanas.Key words
Full text:
1
Index:
LILACS
Main subject:
Breast Neoplasms
/
Cytochrome P-450 CYP1A1
/
Polymorphism, Single Nucleotide
/
INDEL Mutation
/
Cytochrome P-450 CYP1B1
/
Glutathione Transferase
Type of study:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
Country/Region as subject:
Africa
/
Mexico
Language:
En
Journal:
Salud pública Méx
Journal subject:
SAUDE PUBLICA
Year:
2017
Type:
Article