Effects of hypothermia on lung inflammation in a rat model of meconium aspiration syndrome
Acta cir. bras
;
33(6): 483-490, June 2018. tab, graf
Article
in English
| LILACS
| ID: biblio-949354
ABSTRACT
Abstract Purpose:
To evaluate the effects of hypothermia treatment on meconium-induced inflammation.Methods:
Fifteen rats were instilled with human meconium (MEC, 1.5 mL/kg, 65 mg/mL) intratracheally and ventilated for 3 hours. Eight rats that were ventilated and not instilled with meconium served as a sham group. In MEC-hypothermia group, the body temperature was lowered to 33±0.5°C. Analysis of the blood gases, interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor (TNF)-α in bronchoalveolar lavage (BAL) fluid samples, and histological analyses of the lungs were performed.Results:
The BAL fluid TNF-α, IL-1β, IL-6 and IL-8 concentrations were significantly higher in the MEC-hypothermia group than in the MEC-normothermia (p < 0.001, p < 0.001, p = 0.001, p < 0.001, respectively) and sham-controlled groups (p < 0.001, p < 0.001, p < 0.001, p < 0.001, respectively).Conclusion:
Meconium-induced inflammatory cytokine production is affected by the body temperature control.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Pneumonia
/
Meconium Aspiration Syndrome
/
Hypothermia, Induced
Type of study:
Evaluation studies
/
Prognostic study
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2018
Type:
Article
Affiliation country:
Turkey
Institution/Affiliation country:
University of Başkent/TR
/
University of Mersin/TR
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