Tazarotene gel with narrow-band UVB phototherapy: a synergistic combination in psoriasis
An. bras. dermatol
; An. bras. dermatol;93(3): 385-390, May-June 2018. tab, graf
Article
in En
| LILACS
| ID: biblio-949872
Responsible library:
BR1.1
ABSTRACT
Abstract BACKGROUND:
Narrow-band UVB (NB-UVB) has been shown to be one of the most effective treatment modalities for psoriasis. Tazarotene, a known effective anti-psoriatic modality, when combined with NB-UVB may enhance the therapeutic success.OBJECTIVE:
To study clinical efficacy and safety of combination of NB-UVB with topical tazarotene 0.05% gel in psoriasis.METHOD:
Thirty patients with plaque psoriasis having symmetrical lesions were enrolled for 12 weeks. All patients were instructed to apply tazarotene gel on target plaque on left side of body once daily. In addition, the whole body was irradiated with NB-UVB twice weekly. Efficacy was assessed by target plaque scoring and number of treatment sessions for clearance.RESULT:
Our study resulted in 3 keyfindings:
Firstly, therapeutic efficacy of NB-UVB was enhanced by addition of tazarotene. This enhanced efficacy was more apparent in decreasing scaling and thickness as compared to decrease in erythema. Secondly, combination therapy showed faster clearance of target plaques, with reduction in mean number of treatment sessions. Thirdly, mean cumulative NB-UVB dose needed to achieve clearance of target plaques was significantly reduced with combination therapy. STUDYLIMITATIONS:
The study was not randomized or controlled, but an open-label trial. The study period was relatively short, i.e., 12 weeks, without any follow-up period.CONCLUSION:
Tazarotene gel significantly enhances the therapeutic efficacy of NB-UVB irradiation with faster clearance and without serious side effects.Key words
Full text:
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Index:
LILACS
Main subject:
Psoriasis
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Ultraviolet Therapy
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Follow-Up Studies
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Dermatologic Agents
Type of study:
Clinical_trials
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limits:
Adolescent
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Adult
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Female
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Humans
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Male
Language:
En
Journal:
ABD: Anais brasileiros de dermatologia
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An Bras Dermatol
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An. bras. dermatol
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An. bras. dermatol. (Online)
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Anais brasileiros de dermatologia (Impresso)
Journal subject:
DERMATOLOGIA
Year:
2018
Type:
Article