Vitamin D levels in actinic keratosis: a preliminary study
An. bras. dermatol
; 93(4): 535-538, July-Aug. 2018. tab
Article
in En
| LILACS
| ID: biblio-949908
Responsible library:
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ABSTRACT
Abstract Background:
Recent studies that investigated the effect of vitamin D on skin cancer risk have exhibited inconsistent results.Objective:
The aim of the study was to evaluate vitamin D status in patients with actinic keratosis.Methods:
A cross-sectional study was conducted on 31 patients with actinic keratosis and 29 healthy controls. Serum vitamin D levels in the study group were determined by liquid chromatography/tandem mass spectrometry.Results:
Serum 25(OH)D levels in patients with actinic keratosis were significantly higher than those of the healthy controls (P=0.04). Prevalence of 25(OH)D deficiency was significantly higher in the healthy controls (75.9%) compared to the patients with actinic keratosis (54.8%), but the difference was not statistically significant (P= 0.09). Studylimitations:
The cross-sectional design of the study, data on smoking based on patient self-report, and subjects' different dietary habits, which can influence 25(OH)D levels, are the study's limitations.Conclusion:
Serum vitamin D level can be used as a marker for ultraviolet B radiation from sun exposure; therefore, it can be used in individuals at risk of actinic keratosis. Oral intake of vitamin D through diet or supplements is proposed instead of prolonged ultraviolet exposure to maintain adequate vitamin D serum levels. Further research is needed to elucidate the role of vitamin D in skin carcinogenesis.Key words
Full text:
1
Index:
LILACS
Main subject:
Vitamin D
/
Keratosis, Actinic
Type of study:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
En
Journal:
An. bras. dermatol
Journal subject:
DERMATOLOGIA
Year:
2018
Type:
Article