Seroprevalence of hepatitis E virus in chronic hepatitis C in Brazil
Braz. j. infect. dis
;
22(2): 85-91, Mar.-Apr. 2018. tab, graf
Article
in English
| LILACS
| ID: biblio-951634
ABSTRACT
ABSTRACT Background and aims:
Hepatitis E virus infection in patients with underlying chronic liver disease is associated with liver decompensation and increased lethality. The seroprevalence of hepatitis E virus in patients with chronic hepatitis C in Brazil is unknown. This study aims to estimate the seroprevalence of hepatitis E virus in patients with chronic hepatitis C and to describe associated risk factors.Methods:
A total of 618 patients chronically infected with hepatitis C virus from three reference centers of São Paulo, Brazil were included. Presence of anti-HEV IgG was assessed by enzyme-linked immunosorbent assay (WANTAI HEV-IgG ELISA).Results:
Out of the 618 patients tested, 10.2% turned out positive for anti-HEV IgG (95% CI 8.0-12.8%). Higher seroprevalence was found independently associated with age over 60 years (OR = 2.04; p = 0.02) and previous contact with pigs (OR = 1.99; p = 0.03).Conclusions:
Patients with chronic hepatitis C are under risk of hepatitis E virus superinfection in São Paulo. Contact with pigs is a risk factor for the infection, suggesting a possible zoonosis with oral transmission.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Hepatitis Antibodies
/
Hepatitis E virus
/
Hepatitis E
/
Hepatitis C, Chronic
Type of study:
Risk factors
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Braz. j. infect. dis
Journal subject:
Communicable Diseases
Year:
2018
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Hospital de Transplante Euryclides Jesus Zerbini/BR
/
Instituto de Vacinação e Infectologia de Piracicaba/BR
/
Universidade Federal de São Paulo/BR
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