Collagen sponge and rhBMP-2 improve socket healing in rats treated with zoledronic acid
Braz. oral res. (Online)
; 31: e99, 2017. tab, graf
Article
in En
| LILACS
| ID: biblio-952129
Responsible library:
BR1.1
ABSTRACT
Abstract The aim of the present study was to evaluate the possible use of a commercial absorbed collagen sponge and bone morphogenetic protein (BMP) for the prevention of bisphosphonate-related osteonecrosis of the jaw (BRONJ) in rats. Twenty rats received intraperitoneal injections of 0.1-mg/kg of zoledronic acid three times a week for eight weeks before the extraction of both maxillary first molars after eight weeks. A collagen sponge (experimental group 1) and a collagen sponge with recombinant human BMP-2 (experimental group 2) were applied to the right extraction sockets of ten rats each. The 20 left extraction sockets (control groups 1 and 2) were left unprotected. After eight weeks, all rats were euthanized. Macroscopic analysis, micro-computed tomography (CT) analysis, and histological analysis were performed. There was a significant difference in the bone density between the control and experimental groups on micro-CT analysis. Impaired healing of the extraction sockets, indicating BRONJ, was observed in 80% of control group 1, 90% of control group 2, 30% of experimental group 1, and 20% of experimental group 2. The collagen sponge with/without BMP used for protecting the extraction socket had the potential for a positive effect in reducing the incidence of bisphosphonate-related osteonecrosis of the jaw in rats.
Key words
Full text:
1
Index:
LILACS
Main subject:
Wound Healing
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Surgical Sponges
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Transforming Growth Factor beta
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Collagen
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Tooth Socket
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Diphosphonates
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Bone Morphogenetic Protein 2
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Bisphosphonate-Associated Osteonecrosis of the Jaw
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Imidazoles
Limits:
Animals
Language:
En
Journal:
Braz. oral res. (Online)
Journal subject:
ODONTOLOGIA
Year:
2017
Type:
Article