The protective effect of Papaverine and Alprostadil in rat testes after ischemia and reperfusion injury
Int. braz. j. urol
; 44(3): 617-622, May-June 2018. graf
Article
in En
| LILACS
| ID: biblio-954058
Responsible library:
BR1.1
ABSTRACT
ABSTRACT Objective:
To investigate the effect of papaverine and alprostadil on testicular torsion-detorsion injury in rats. Materials andMethods:
A total of 40 male Wistar-Albino rats were used in this study. Four hours of right testicular torsion was applied to each group, excluding sham oper- ated group. The torsion-detorsion (T/D), T/D + papaverine and T/D + alprostadil groups received saline, papaverine and alprostadil at the same time as surgical detorsion, respectively. At 14 days after the surgical detorsion, ischaemic changes and the degree of damage were evaluated with Cosentino scoring and the Johnson tubular biopsy score (JTBS).Results:
JTBS was determined as 8.8±2.7 in the Sham group, 5.08±1.9 in the T/D+papaverine group, 5.29±2.3 in the T/D +alprostadil group and 2.86±1.9 in the TD group. The JTBS was determined to be statistically significantly high in both the T/D + papaverine group and the T/D + alprostadil group compared to the T/D group (p=0.01, p=0.009). In the T/D + papaverine group, 3 (43%) testes were classified as Cosentino 2, 3 (43%) as Cosentino 3 and 1 (14%) as Cosentino 4. In the T/D +alprostadil group, 5 (50 %) testes were classified as Cosentino 2, 3 (30 %) as Cosentino 3 and 2 (20%) as Cosentino 4.Conclusion:
The present study indicated that spermatic cord administration of alprostadil and papaverine showed a protective effect against ischemia/reperfusion injury after right-side testes torsion and histological changes were decreased after testicular ischemia reperfusion injury.Key words
Full text:
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Index:
LILACS
Main subject:
Papaverine
/
Spermatic Cord Torsion
/
Testis
/
Vasodilator Agents
/
Alprostadil
/
Ischemia
Type of study:
Evaluation_studies
Limits:
Animals
Language:
En
Journal:
Int. braz. j. urol
Journal subject:
UROLOGIA
Year:
2018
Type:
Article