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Protective effects of melatonin on spinal cord injury / Efectos protectores de la melatonina en lesión de la médula espinal
Baran, Özlem; Çiçekçi, Esra; Dönder, Ahmet; Atiç, Ramazan; Deveci, Engin; Tuncer, Mehmet Cudi.
Affiliation
  • Baran, Özlem; Dicle University School of Medicine. Department of Histology and Embryology. Diyarbakir. TR
  • Çiçekçi, Esra; Diyarbakir Gazi Yasargil Education and Research Hospital. Department of Physiotheraphy. Diyarbakir. TR
  • Dönder, Ahmet; Dicle University. Ataturk Health High School. Diyarbakir. TR
  • Atiç, Ramazan; University of Dicle. Faculty of Medicine. Department of Orthopaedic and Traumatology. Diyarbakir. TR
  • Deveci, Engin; Dicle University School of Medicine. Department of Histology and Embryology. Diyarbakir. TR
  • Tuncer, Mehmet Cudi; Dicle University School of Medicine. Department of Anatomy. Diyarbakir. TR
Int. j. morphol ; 36(2): 488-492, jun. 2018. tab, graf
Article in En | LILACS | ID: biblio-954142
Responsible library: CL1.1
ABSTRACT
Spinal cord injury causes neuron nerve fiber loss. The aim of this study was to investigate the neuroprotective, inflammatory and angiogenetic effects of melatonin on rat spinal cord injury (SCI). For spinal cord injury, a standard weight reduction method was used that caused moderate severity of injury (100 g / cm force) at T10 Melatonin (10 mg/kg intraperitoneally ) was administered for 10 days after trauma. Each group consisted of 10 animals. of these, six were used for biochemical and four were used for the evaluation of histological analysis. Spinal cord samples were taken for histological examination or determination of malondialdehyde (MDA) and glutathione (GSH) levels, myeloperoxidase (MPO) activity. Spinal cord injury and melatonin treated group were compared. Melatonin administration in spinal cord injury increased the activity of glial cells in the radial and funicular cells and ependymal cells and increased the activity of glial cells and also showed a positive effect on inflammation and vascular endothelial cells in synaptic connections in the nerve fibers undergoing spinal injury endothelial degeneration It is thought that it can regulate the degenerative effect which is caused by both the inflammatory effect and the angiogenic effect which will have a positive effect on the neural connection.
RESUMEN
La lesión de la médula espinal (SCI) provoca daño en la fibra nerviosa, que puede conducir a alteraciones motoras y sensitivas, incluso la muerte. El objetivo de este estudio fue investigar los efectos neuroprotectores, proinflamatorios y proangiogénicos de la melatonina en un modelo de SCI inducida en rata. Para tal efecto se utilizaron dos grupos Grupo 1 (n10) se le indujo una SCI, mediante el método de reducción de peso estándar (100 g/cm fuerza), provocando una lesión de severidad moderada. Grupo 2 (n10) inducción SCI más aplicación de T10 Melatonina (10 mg / kg v.i.) durante 10 días después del trauma. Muestras de seis animales de cada grupo fueron usados para análisis bioquímicos y los otros cuatro para la evaluación histológica. Se tomaron muestras de médula espinal para el examen histológico y para la determinación de niveles de malondialdehído (MDA) y glutatión (GSH), actividad mieloperoxidasa (MPO) y se comparó la lesión de la médula espinal y el grupo tratado con melatonina. La administración de melatonina en la lesión de la médula espinal aumentó la actividad de las células gliales en las células radiales, funiculares y ependimocitos. Ademas mostró un efecto positivo sobre la inflamación y angiogénesis en las conexiones sinápticas en las fibras nerviosas sometidas a lesión espinal. Pudiendo este participar en la regulación del efecto degenerativo causado, principalmente, por acción de angiogénesis e inflamación local.
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Full text: 1 Index: LILACS Main subject: Spinal Cord Injuries / Melatonin Type of study: Prognostic_studies Language: En Journal: Int. j. morphol Journal subject: ANATOMIA Year: 2018 Type: Article

Full text: 1 Index: LILACS Main subject: Spinal Cord Injuries / Melatonin Type of study: Prognostic_studies Language: En Journal: Int. j. morphol Journal subject: ANATOMIA Year: 2018 Type: Article